THE EFFECT OF THIAZOLIDENEDIONE ON GLUCOCORTICOID INDUCED CENTRAL OBESITY IN RATS

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SOVEYD MAHMOUD; KALANTAR HORMOZI M.R.; AZIZI Z.A.; RANJBAR OMRANI GH.H.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2009 | Volume:10 | Issue:5 (SN 41) Page(s): 527-532

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Title

THE EFFECT OF THIAZOLIDENEDIONE ON GLUCOCORTICOID INDUCED CENTRAL OBESITY IN RATS

Author(s)

SOVEYD MAHMOUD | KALANTAR HORMOZI M.R. | AZIZI Z.A. | RANJBAR OMRANI GH.H. | Issue Writer Certificate

Keywords

PIOGLITAZONEQ3

GLUCOCORTICOIDQ3

CENTRAL OBESITYQ3

THIAZOLIDINEDIONEQ3

Abstract

Introduction: CENTRAL OBESITY is a common complication of GLUCOCORTICOIDs which is associated with insulin resistance. In some studies, THIAZOLIDINEDIONEs have decreased CENTRAL OBESITY in type 2 diabetic patients. The purpose of this study was to investigate the effect of PIOGLITAZONE on GLUCOCORTICOID induced CENTRAL OBESITY in rats. Materials and Methods: Forty Sprague-Daily rats were divided into 2 groups, with 10 male and 10 female rats in each. In group 1, methylprednisolone succinate 5 mg/kg was injected 3 times per week and PIOGLITAZONE 30 mg/kg/day was given. In group 2, only methylprednisolone succinate was administered. After 3 weeks, the rats were sacrificed and visceral fat was removed, and the weight of visceral fat, abdomen circumference and total body weight in the 2 groups were compared. Results: The weight of animals was not different significantly; however animals given PIOGLITAZONE had less visceral fat (7.32±2.60 vs 11.95±2.76 gr P<0.001) and lower abdominal circumference (11.92±1.20 vs 14.98±1.74 cm P<0.001). Conclusion: PIOGLITAZONE has antagonistic effect on GLUCOCORTICOID induced CENTRAL OBESITY.

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APA: Copy

SOVEYD, MAHMOUD, KALANTAR HORMOZI, M.R., AZIZI, Z.A., & RANJBAR OMRANI, GH.H.. (2009). THE EFFECT OF THIAZOLIDENEDIONE ON GLUCOCORTICOID INDUCED CENTRAL OBESITY IN RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(5 (SN 41)), 527-532. SID. https://sid.ir/paper/27458/en

Vancouver: Copy

SOVEYD MAHMOUD, KALANTAR HORMOZI M.R., AZIZI Z.A., RANJBAR OMRANI GH.H.. THE EFFECT OF THIAZOLIDENEDIONE ON GLUCOCORTICOID INDUCED CENTRAL OBESITY IN RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2009;10(5 (SN 41)):527-532. Available from: https://sid.ir/paper/27458/en

IEEE: Copy

MAHMOUD SOVEYD, M.R. KALANTAR HORMOZI, Z.A. AZIZI, and GH.H. RANJBAR OMRANI, “THE EFFECT OF THIAZOLIDENEDIONE ON GLUCOCORTICOID INDUCED CENTRAL OBESITY IN RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 5 (SN 41), pp. 527–532, 2009, [Online]. Available: https://sid.ir/paper/27458/en

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