STUDY OF SEDATIVE PREANAESTHETIC AND ANXIOLYTIC EFFECTS OF HERBAL EXTRACT OF TILIA PLATYPHYLLOS SCOP IN COMPARISON WITH DIAZEPAM IN THE RAT

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REZAIE A.; JAFARI B.; AHMADIZADEH CH.; JALILZADEH HEDAYATI M.; OSTADI Z.; EBADI A.R.; SHISHEGAR R.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2011 | Volume:5 | Issue:1 (17) Page(s): 1051-1058

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Title

STUDY OF SEDATIVE PREANAESTHETIC AND ANXIOLYTIC EFFECTS OF HERBAL EXTRACT OF TILIA PLATYPHYLLOS SCOP IN COMPARISON WITH DIAZEPAM IN THE RAT

Author(s)

Keywords

TILIA PLATYPHYLLOS SCOPQ2

SEDATIVEQ2

ANXIOLYTICQ2

DIAZEPAMQ3

ELEVATED PLUS MAZEQ3

Abstract

Tilia platyphyllosscop belongs to the Tiliaceae family and mainly grows in northern parts of the country. It has various pharmacological effects including ANXIOLYTIC, antibacterial, anticonvulsant, spasmolytic, tranquilization and sedation, hypnotic and muscular relaxation. In order to study SEDATIVE, preanaesthetic and ANXIOLYTIC effects herbal extract of TILIA PLATYPHYLLOS SCOP in comparison with DIAZEPAM in different groups of female Wistar rats with the same age and weight, doses of 150 mg/kg, 300 mg/kg and 450 mg/kg of herbal extract, 1.2 mg/kg of DIAZEPAM and equal volumes of dimethyl sulfoxide as a placebo were injected to rats intraperitoneally 30 minutes prior to evaluation of SEDATIVE and preanaesthetic effects (induced sleep duration following 40 mg/kg administration intraperitoneally) and ANXIOLYTIC effects (using ELEVATED PLUS MAZE and Rotarod test). Statistical results obtained represent a significant increase in sleep time induced with ketamine and also a significant increase in time spent by rats in open arms of maze with high and low doses ofTILIA PLATYPHYLLOS SCOP herbal extract (p<0.01). The result showed that herbal extract ofTILIA PLATYPHYLLOS SCOP at a dose of 300 mg/kg has SEDATIVE, preanaesthetic and ANXIOLYTIC effects.

Cites

EFFECT OF MEDICINAL PLANTS ON ANXIETY, A REVIEW ARTICLE

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APA: Copy

REZAIE, A., JAFARI, B., AHMADIZADEH, CH., JALILZADEH HEDAYATI, M., OSTADI, Z., EBADI, A.R., & SHISHEGAR, R.. (2011). STUDY OF SEDATIVE PREANAESTHETIC AND ANXIOLYTIC EFFECTS OF HERBAL EXTRACT OF TILIA PLATYPHYLLOS SCOP IN COMPARISON WITH DIAZEPAM IN THE RAT. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 5(1 (17)), 1051-1058. SID. https://sid.ir/paper/183319/en

Vancouver: Copy

REZAIE A., JAFARI B., AHMADIZADEH CH., JALILZADEH HEDAYATI M., OSTADI Z., EBADI A.R., SHISHEGAR R.. STUDY OF SEDATIVE PREANAESTHETIC AND ANXIOLYTIC EFFECTS OF HERBAL EXTRACT OF TILIA PLATYPHYLLOS SCOP IN COMPARISON WITH DIAZEPAM IN THE RAT. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2011;5(1 (17)):1051-1058. Available from: https://sid.ir/paper/183319/en

IEEE: Copy

A. REZAIE, B. JAFARI, CH. AHMADIZADEH, M. JALILZADEH HEDAYATI, Z. OSTADI, A.R. EBADI, and R. SHISHEGAR, “STUDY OF SEDATIVE PREANAESTHETIC AND ANXIOLYTIC EFFECTS OF HERBAL EXTRACT OF TILIA PLATYPHYLLOS SCOP IN COMPARISON WITH DIAZEPAM IN THE RAT,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 5, no. 1 (17), pp. 1051–1058, 2011, [Online]. Available: https://sid.ir/paper/183319/en

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