STUDY OF SEDATIVE, PREANAESTHETIC AND ANTI-ANXIETY EFFECTS OF ROSA DAMASCENE HERBAL EXTRACT IN COMPARISON WITH DIAZEPAM IN RAT

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REZAIE ALI; MOSAVI GHAFOUR; AHMADIZADEH CHANGIZ; JAFARI BEHBOUD

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Journal: Tehran University Medical Journal Year:2011 | Volume:69 | Issue:3 Page(s): 179-183

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Title

STUDY OF SEDATIVE, PREANAESTHETIC AND ANTI-ANXIETY EFFECTS OF ROSA DAMASCENE HERBAL EXTRACT IN COMPARISON WITH DIAZEPAM IN RAT

Author(s)

REZAIE ALI | MOSAVI GHAFOUR | AHMADIZADEH CHANGIZ | JAFARI BEHBOUD | Issue Writer Certificate

Keywords

ANXIOLYTICQ2

DIAZEPAMQ2

ELEVATED PLUS MAZEQ2

ROSA DAMASCENEQ3

SEDATIVEQ2

Abstract

Background: ROSA DAMASCENE has a special role in the Iranian traditional medicine due to its SEDATIVE, anticonvulsant and analgesic effects. Regarding its alkaloid, flavonoid and other organic compounds, this plant has always been used to reduce nervousness and treat depression and chronic insomnia. In the present time, synthetic drugs with SEDATIVE and ANXIOLYTIC properties are used for such problems but due to their sideeffects and economic issues, the significance of natural medicines with fewer sideeffects is of interest. Considering the importance of SEDATIVE and ANXIOLYTIC effects of ROSA DAMASCENE, we decided to compare this plant with synthetic drugs of the same properties.Methods: Two different groups of male Wistar rats received either ROSA DAMASCENE extract in doses of 150, 300, 450 mg/kg or DIAZEPAM and dimethyl sulphoxide in doses of 1.2 mg/kg intraperitoneally 30 minutes before assessing the sleep duration, sedation and preanesthetic effects induced by intraperitoneal ketamine, 40 mg/kg. The antianxiety effect was evaluated by using an ELEVATED PLUS MAZE and a rota rod.Results: The results showed a meaningful increase in the period of sleep induced by Ketamine (P.0.01) and also a meaningful increase in time spent at the open arms of the device in the group receiving ROSA DAMASCENE extract (P.0.01).Conclusion: The results showed that the ROSA DAMASCENE extract dose 450mg/kg has SEDATIVE, preanesthetic and ANXIOLYTIC effects (P.0.01).

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APA: Copy

REZAIE, ALI, MOSAVI, GHAFOUR, AHMADIZADEH, CHANGIZ, & JAFARI, BEHBOUD. (2011). STUDY OF SEDATIVE, PREANAESTHETIC AND ANTI-ANXIETY EFFECTS OF ROSA DAMASCENE HERBAL EXTRACT IN COMPARISON WITH DIAZEPAM IN RAT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 69(3), 179-183. SID. https://sid.ir/paper/39059/en

Vancouver: Copy

REZAIE ALI, MOSAVI GHAFOUR, AHMADIZADEH CHANGIZ, JAFARI BEHBOUD. STUDY OF SEDATIVE, PREANAESTHETIC AND ANTI-ANXIETY EFFECTS OF ROSA DAMASCENE HERBAL EXTRACT IN COMPARISON WITH DIAZEPAM IN RAT. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2011;69(3):179-183. Available from: https://sid.ir/paper/39059/en

IEEE: Copy

ALI REZAIE, GHAFOUR MOSAVI, CHANGIZ AHMADIZADEH, and BEHBOUD JAFARI, “STUDY OF SEDATIVE, PREANAESTHETIC AND ANTI-ANXIETY EFFECTS OF ROSA DAMASCENE HERBAL EXTRACT IN COMPARISON WITH DIAZEPAM IN RAT,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 69, no. 3, pp. 179–183, 2011, [Online]. Available: https://sid.ir/paper/39059/en

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