EFFECTS OF BIEBERSTEINIA MULTIFIDA DC ROOT EXTRACT ON PERPHENAZINE-INDUCED CATATONIA IN MALE MICE

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KHAKPOUR SH.; HADIPOUR JAHROMY M.

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Paper Information

Journal: BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN) Year:2008 | Volume:3 | Issue:3 Page(s): 7-11

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Title

EFFECTS OF BIEBERSTEINIA MULTIFIDA DC ROOT EXTRACT ON PERPHENAZINE-INDUCED CATATONIA IN MALE MICE

Author(s)

KHAKPOUR SH. | HADIPOUR JAHROMY M. | Issue Writer Certificate

Keywords

MUSCULAR RIGIDITYQ3

BIEBERSTEINIA MULTIFIDA DC ROOT EXTRACTQ3

CATATONIAQ3

PERPHENAZINEQ3

Abstract

Catatonia is one of the major signs of Parkinson's disease due to impaired dopamine in extra pyramidal system. So far, effects of many plants on neuronal and movement disorders have been evaluated, some of which are accepted in clinical studies. In the present research, the effect of BIEBERSTEINIA MULTIFIDA DC ROOT EXTRACT on PERPHENAZINE-induced CATATONIA in male mice was studied.The root extract (10, 25, 50, 100 mg/kg) was orally administered to mice for two weeks. Control group received water for two weeks, as well. One hour after the last dose, PERPHENAZINE (5 mg/kg) was administered (IP) to induce CATATONIA. MUSCULAR RIGIDITY of animals was determined by scoring method of Morpurgo. Results showed that BIEBERSTEINIA MULTIFIDA DC ROOT EXTRACT at doses 10, 25 and 50 mg/kg increased rigidity while administration of higher dose of 100 mg/kg could improve MUSCULAR RIGIDITY.Therefore, it is concluded that Biebersteinia multifida DC, at low doses, probably, by blocking D2 receptors in dopaminergic pathways (mesocortical-mesolimbic) potentiates PERPHENAZINE-induced CATATONIA, and in higher dose, reduced signs of PERPHENAZINE-induced CATATONIA probably via effects on dopaminergic system in nigro-striatal pathway.

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APA: Copy

KHAKPOUR, SH., & HADIPOUR JAHROMY, M.. (2008). EFFECTS OF BIEBERSTEINIA MULTIFIDA DC ROOT EXTRACT ON PERPHENAZINE-INDUCED CATATONIA IN MALE MICE. BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN), 3(3), 7-11. SID. https://sid.ir/paper/183713/en

Vancouver: Copy

KHAKPOUR SH., HADIPOUR JAHROMY M.. EFFECTS OF BIEBERSTEINIA MULTIFIDA DC ROOT EXTRACT ON PERPHENAZINE-INDUCED CATATONIA IN MALE MICE. BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN)[Internet]. 2008;3(3):7-11. Available from: https://sid.ir/paper/183713/en

IEEE: Copy

SH. KHAKPOUR, and M. HADIPOUR JAHROMY, “EFFECTS OF BIEBERSTEINIA MULTIFIDA DC ROOT EXTRACT ON PERPHENAZINE-INDUCED CATATONIA IN MALE MICE,” BIOLOGICAL SCIENCES (DANISH-I ZISTI-I IRAN), vol. 3, no. 3, pp. 7–11, 2008, [Online]. Available: https://sid.ir/paper/183713/en

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