CYTOCIDAL EFFECTS OF BACILLUS THURINGIENSIS CRYSTAL PROTEIN ON MICE BREAST CANCER CELL LINE IN IN VITRO CONDITION

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BIAZAR SH.; MOAZAMIAN E.; AZARPIRA N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: JOURNAL OF CELL & TISSUE Year:2016 | Volume:7 | Issue:3 Page(s): 243-250

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Information Journal Paper

Title

CYTOCIDAL EFFECTS OF BACILLUS THURINGIENSIS CRYSTAL PROTEIN ON MICE BREAST CANCER CELL LINE IN IN VITRO CONDITION

Author(s)

BIAZAR SH. | MOAZAMIAN E. | AZARPIRA N. | Issue Writer Certificate

Keywords

BACILLUS THURINGIENSISQ2

PARASPORINQ1

BREAST CANCER CELL LINEQ1

CYTOTOXICITY ACTIVITYQ1

Abstract

Aim: In the study, the effects of BACILLUS THURINGIENSIS PARASPORIN were examined on mice cancer cell line (4T1).Material and Methods: Purification of crystal toxins was done from the isolates of B. thuringiensis.Breast cancer cells line 4T1 were treated with activated toxins. Cytopathic effects were photographed.Crystal toxin with the most cytotoxicity was identified by using SDS-PAGE and also molecular method.Results: From forty seven tested isolates of B. thuringiensis, E8 isolate shown the most cytotoxicity effect on 4T1 cell line. In addition, PARASPORIN-4 was identified by using SDS-PAGE and PCR methods. PARASPORIN-4 disintegrated 4T1 cell line and it has cytolysin effects.Conclusion: Our data suggest that, PARASPORIN is cytolysin protein and has a specific site on the cell surface. This crystal protein can induce apoptosis in BREAST CANCER CELL LINE.

Cites

MOLECULAR IDENTIFICATION, ISOLATION AND EVALUATION OF PERSIAN GULF ACTINOMYCETES AS CANDIDATES OF CYTOTOXIC METABOLITES AGAINST BREAST CANCER

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APA: Copy

BIAZAR, SH., MOAZAMIAN, E., & AZARPIRA, N.. (2016). CYTOCIDAL EFFECTS OF BACILLUS THURINGIENSIS CRYSTAL PROTEIN ON MICE BREAST CANCER CELL LINE IN IN VITRO CONDITION. JOURNAL OF CELL & TISSUE, 7(3 ), 243-250. SID. https://sid.ir/paper/188890/en

Vancouver: Copy

BIAZAR SH., MOAZAMIAN E., AZARPIRA N.. CYTOCIDAL EFFECTS OF BACILLUS THURINGIENSIS CRYSTAL PROTEIN ON MICE BREAST CANCER CELL LINE IN IN VITRO CONDITION. JOURNAL OF CELL & TISSUE[Internet]. 2016;7(3 ):243-250. Available from: https://sid.ir/paper/188890/en

IEEE: Copy

SH. BIAZAR, E. MOAZAMIAN, and N. AZARPIRA, “CYTOCIDAL EFFECTS OF BACILLUS THURINGIENSIS CRYSTAL PROTEIN ON MICE BREAST CANCER CELL LINE IN IN VITRO CONDITION,” JOURNAL OF CELL & TISSUE, vol. 7, no. 3 , pp. 243–250, 2016, [Online]. Available: https://sid.ir/paper/188890/en

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