INDUCTION OF DIFFERENTIATION AND CELL DEATH OF THE DERIVATIVE OF 4-ARYL-4H-CHROMENES FAMILY ON NB4 HUMAN PROMYELOCYTIC LEUKEMIA CELL LINE

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NASERI M.H.; HESSAMI TACKALLOU S.; MAHDAVI M.; MOOSAVI M.A.; ABASALTI S.; FOROUMADI A.

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Journal: JOURNAL OF CELL & TISSUE Year:2013 | Volume:4 | Issue:2 Page(s): 139-147

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Title

INDUCTION OF DIFFERENTIATION AND CELL DEATH OF THE DERIVATIVE OF 4-ARYL-4H-CHROMENES FAMILY ON NB4 HUMAN PROMYELOCYTIC LEUKEMIA CELL LINE

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Keywords

ACUTE PROMYELOCYTIC LEUKEMIAQ2

APOPTOSISQ2

4-ARYL-4H-CHROMENESQ2

DIFFERENTIATIONQ2

NB4 CELLQ2

Abstract

Aim: Chromene derivatives are able to growth inhibition and induce APOPTOSIS in different cell types. In this study, we reported a derivative of 4-ARYL-4H-CHROMENES with DIFFERENTIATION and apoptotic activity against NB4, ACUTE PROMYELOCYTIC LEUKEMIA (APL) cell.Matherial and Methods: The cells were seeded in 24-well plates at 1´105 cells/well and treated with 1−12 nM of the 2-amino- 4- (3-bromo 4, 5 dimethoxy-phenyl) -3- cyano -7- (dimethylamino) -4H-chromene (3-BMPC). This compound inhibited growth and viability of the cells in dose- and time-dependent manner. 3-BMPC was found to be highly active growth inhibitor with IC50 of 3 nM (72h) as determined by trypan blue exclusion test. Wright-Giemsa staining and latex particle phagocytosis assay were used to study differentiated cells. APOPTOSIS was also detected by fluorescent microscope and DNA fragmentation assay.Results: Results indicated that at low concentrations (3 nM) and after 48 h of treatment, NB4 CELLs were differentiated to monocyte/macrophage lineage. Results of Hoechst 33258 staining also revealed that the compound induced APOPTOSIS at respective IC50 value after 72 h of treatment. Conclusion: Regarding these results, this compound can be proposed as effective agents for more investigation in leukemia treatment.

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APA: Copy

NASERI, M.H., HESSAMI TACKALLOU, S., MAHDAVI, M., MOOSAVI, M.A., ABASALTI, S., & FOROUMADI, A.. (2013). INDUCTION OF DIFFERENTIATION AND CELL DEATH OF THE DERIVATIVE OF 4-ARYL-4H-CHROMENES FAMILY ON NB4 HUMAN PROMYELOCYTIC LEUKEMIA CELL LINE. JOURNAL OF CELL & TISSUE, 4(2), 139-147. SID. https://sid.ir/paper/188964/en

Vancouver: Copy

NASERI M.H., HESSAMI TACKALLOU S., MAHDAVI M., MOOSAVI M.A., ABASALTI S., FOROUMADI A.. INDUCTION OF DIFFERENTIATION AND CELL DEATH OF THE DERIVATIVE OF 4-ARYL-4H-CHROMENES FAMILY ON NB4 HUMAN PROMYELOCYTIC LEUKEMIA CELL LINE. JOURNAL OF CELL & TISSUE[Internet]. 2013;4(2):139-147. Available from: https://sid.ir/paper/188964/en

IEEE: Copy

M.H. NASERI, S. HESSAMI TACKALLOU, M. MAHDAVI, M.A. MOOSAVI, S. ABASALTI, and A. FOROUMADI, “INDUCTION OF DIFFERENTIATION AND CELL DEATH OF THE DERIVATIVE OF 4-ARYL-4H-CHROMENES FAMILY ON NB4 HUMAN PROMYELOCYTIC LEUKEMIA CELL LINE,” JOURNAL OF CELL & TISSUE, vol. 4, no. 2, pp. 139–147, 2013, [Online]. Available: https://sid.ir/paper/188964/en

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