FISH STUDY OF CHROMOSOME 15 IN A MODEL EFFECTED WITH ENDOMETRIAL ADENOCARCINOMA CANCER

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HAMTA A.; SHAHRJERDIE A.R.; SHAYESTEH FAR A.R.; NASR ABADIE T.

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Journal: JOURNAL OF CELL & TISSUE Year:2011 | Volume:2 | Issue:1 Page(s): 17-24

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Title

FISH STUDY OF CHROMOSOME 15 IN A MODEL EFFECTED WITH ENDOMETRIAL ADENOCARCINOMA CANCER

Author(s)

HAMTA A. | SHAHRJERDIE A.R. | SHAYESTEH FAR A.R. | NASR ABADIE T. | Issue Writer Certificate

Keywords

ENDOMETRIAL ADENOCARCINOMAQ2

FISHQ2

PAINTQ2

BDII INBRED RATQ2

Abstract

Aim: Main goal of this investigation were verification of gene's behavior which located on RNO15 with allelic imbalance during Endometrium cancer development.Material and methods: BDII/Han females were crossed to males from two other inbred rat strains known to have low incidence of EAC (BN/Han and SPRD-Cu3/Han). To generate F2 rats the F1 animals were intercrossed. In addition, backcross populations were generated by crossing male F1 rats to female BDII rats. In order to characterize these tumor-specific genetic aberrations in greater detail, we applied molecular cytogenetic methods (FISH, chromosome PAINTing) to 18 rat ENDOMETRIAL ADENOCARCINOMA (EAC) cell cultures.Results: Analysis in the tumors by FISH analysis showed the presence of small regions of amplifications.Conclusion: These changes were cryptic so that they occurred inside cytogenetically normal-looking chromosomes. We detected rather specific chromosome aberrations (translocations, deletions, amplifications) often leading to copy number changes in small DNA segments (gains, losses.(

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APA: Copy

HAMTA, A., SHAHRJERDIE, A.R., SHAYESTEH FAR, A.R., & NASR ABADIE, T.. (2011). FISH STUDY OF CHROMOSOME 15 IN A MODEL EFFECTED WITH ENDOMETRIAL ADENOCARCINOMA CANCER. JOURNAL OF CELL & TISSUE, 2(1), 17-24. SID. https://sid.ir/paper/188982/en

Vancouver: Copy

HAMTA A., SHAHRJERDIE A.R., SHAYESTEH FAR A.R., NASR ABADIE T.. FISH STUDY OF CHROMOSOME 15 IN A MODEL EFFECTED WITH ENDOMETRIAL ADENOCARCINOMA CANCER. JOURNAL OF CELL & TISSUE[Internet]. 2011;2(1):17-24. Available from: https://sid.ir/paper/188982/en

IEEE: Copy

A. HAMTA, A.R. SHAHRJERDIE, A.R. SHAYESTEH FAR, and T. NASR ABADIE, “FISH STUDY OF CHROMOSOME 15 IN A MODEL EFFECTED WITH ENDOMETRIAL ADENOCARCINOMA CANCER,” JOURNAL OF CELL & TISSUE, vol. 2, no. 1, pp. 17–24, 2011, [Online]. Available: https://sid.ir/paper/188982/en

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