THE EVALUATION OF INT1, SUL1, AADA2, AND AADB GENES FREQUENCIES IN CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII IN TEHRAN

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HOSSEINI FARZANEH; SALIMIZADEH ZAHRA; SALEHI MITRA

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Journal: JOURNAL OF MICROBIAL WORLD Year:2017 | Volume:9 | Issue:4 (29) Page(s): 297-306

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Title

THE EVALUATION OF INT1, SUL1, AADA2, AND AADB GENES FREQUENCIES IN CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII IN TEHRAN

Author(s)

HOSSEINI FARZANEH | SALIMIZADEH ZAHRA | SALEHI MITRA | Issue Writer Certificate

Keywords

ACINETOBACTER BAUMANNIIQ2

INTEGRON CLASS 1Q1

ANTIBIOTIC RESISTANCEQ2

Abstract

Background & Objectives: ACINETOBACTER BAUMANNII a is a gram-negative coccobacillus which is increasingly reported as the major cause of nosocomial infections. The aim of this study was to determine the frequency of class I integron, and the prevalence of two important aminoglycoside modifying enzymese genes (aadA2 and aadB) in A. baumannii isolates.Materials & Methods: This cross-sectional study was performed on 33 A. baumannii isolated from patients who referred to Baghiatallah Azam and Shahid Modarres Hospitals in Tehran. Antimicrobial susceptibility of isolates was evaluated using disk diffusion method in accordance with CLSI guideline. The presence of intI1, sul1, aadA2 and aadB genes in clinical isolates was investigated by PCR technique.Results: The frequency of intI1, sul1, aadA2, and aadB genes in A. baumannii was observed as 51.5%, 51.5%, 24.2% and 36.4%, respectively. All isolates were multi-drug resistant, and the highest level of ANTIBIOTIC RESISTANCE was shown to ampicillin, cefixime, cephalothin, nalidixic acid, clindamycin, chloramphenicol, sulfamethoxazole-trimethoprim, and streptomycin (100%). Furthermore, the minimum ANTIBIOTIC RESISTANCE was shown to gentamicin (66.7%), and tetracycline (69.7%).Conclusion: A significant correlation was observed between class 1 integrons, and resistance to one antibiotic. However, this association was not remarkable in several other isolates with antibiotics resistance. This may imply that in addition to integrons, other determinants such as transposons and plasmids may also contribute to resistance.

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APA: Copy

HOSSEINI, FARZANEH, SALIMIZADEH, ZAHRA, & SALEHI, MITRA. (2017). THE EVALUATION OF INT1, SUL1, AADA2, AND AADB GENES FREQUENCIES IN CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII IN TEHRAN. JOURNAL OF MICROBIAL WORLD, 9(4 (29)), 297-306. SID. https://sid.ir/paper/189224/en

Vancouver: Copy

HOSSEINI FARZANEH, SALIMIZADEH ZAHRA, SALEHI MITRA. THE EVALUATION OF INT1, SUL1, AADA2, AND AADB GENES FREQUENCIES IN CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII IN TEHRAN. JOURNAL OF MICROBIAL WORLD[Internet]. 2017;9(4 (29)):297-306. Available from: https://sid.ir/paper/189224/en

IEEE: Copy

FARZANEH HOSSEINI, ZAHRA SALIMIZADEH, and MITRA SALEHI, “THE EVALUATION OF INT1, SUL1, AADA2, AND AADB GENES FREQUENCIES IN CLINICAL ISOLATES OF ACINETOBACTER BAUMANNII IN TEHRAN,” JOURNAL OF MICROBIAL WORLD, vol. 9, no. 4 (29), pp. 297–306, 2017, [Online]. Available: https://sid.ir/paper/189224/en

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