THE INHIBITORY EFFECT OF DOXYCYCLINE- SILVER NANOPARTICLE CONJUGATE ON BRUCELLA MELITENSIS

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AJALLI MOHSEN; SALOUTI MOJTABA; ALIZADEH HAMED; HEYDARI ZAHRA; HAMZEIY HOSSEIN; ALIZADEH ARAM

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Journal: JOURNAL OF MICROBIAL WORLD Year:2010 | Volume:3 | Issue:2 (7) Page(s): 94-100

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Title

THE INHIBITORY EFFECT OF DOXYCYCLINE- SILVER NANOPARTICLE CONJUGATE ON BRUCELLA MELITENSIS

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Keywords

ANTIMICROBIAL EFFECTQ2

SILVER NANOPARTICLESQ2

DOXYCYCLINEQ3

BRUCELLAQ2

Abstract

Background and Objective: Brucellosis is a zoonotic disease caused by BRUCELLA bacteria. According to recent studies, antimicrobial activity of silver nanoparticle was approved. The aim of this study was to investigate the antimicrobial activity of DOXYCYCLINE - SILVER NANOPARTICLES conjugate against BRUCELLA meltensis 16M.Material and Methods: After preparing the DOXYCYCLINE-silver nanoparticle conjugate, its antimicrobial activity against BRUCELLA meltensis 16M was determined by Well Diffusion Agar method in Muller Hintone Agar media. Also, Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of DOXYCYCLINE-silver nanoparticle conjugate was determined by Macrodilution method in Muller Hintone Broth media. Finally, antibacterial effect of the nanoparticle was assayed in animal model.Results: The results showed that DOXYCYCLINE-silver nanoparticle conjugate has antimicrobial activity against BRUCELLA melitensis 16M in laboratory condition. In mouse model, the conjugate of DOXYCYCLINE-silver nanoparticle could decrease effectively the BRUCELLA melitensis load in liver.Conclusion: This study demonstrated that DOXYCYCLINE-silver nanoparticle conjugate has synergistic effect on BRUCELLA melitensis 16M and can be useful in treatment of brucellosis.

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APA: Copy

AJALLI, MOHSEN, SALOUTI, MOJTABA, ALIZADEH, HAMED, HEYDARI, ZAHRA, HAMZEIY, HOSSEIN, & ALIZADEH, ARAM. (2010). THE INHIBITORY EFFECT OF DOXYCYCLINE- SILVER NANOPARTICLE CONJUGATE ON BRUCELLA MELITENSIS. JOURNAL OF MICROBIAL WORLD, 3(2 (7)), 94-100. SID. https://sid.ir/paper/189369/en

Vancouver: Copy

AJALLI MOHSEN, SALOUTI MOJTABA, ALIZADEH HAMED, HEYDARI ZAHRA, HAMZEIY HOSSEIN, ALIZADEH ARAM. THE INHIBITORY EFFECT OF DOXYCYCLINE- SILVER NANOPARTICLE CONJUGATE ON BRUCELLA MELITENSIS. JOURNAL OF MICROBIAL WORLD[Internet]. 2010;3(2 (7)):94-100. Available from: https://sid.ir/paper/189369/en

IEEE: Copy

MOHSEN AJALLI, MOJTABA SALOUTI, HAMED ALIZADEH, ZAHRA HEYDARI, HOSSEIN HAMZEIY, and ARAM ALIZADEH, “THE INHIBITORY EFFECT OF DOXYCYCLINE- SILVER NANOPARTICLE CONJUGATE ON BRUCELLA MELITENSIS,” JOURNAL OF MICROBIAL WORLD, vol. 3, no. 2 (7), pp. 94–100, 2010, [Online]. Available: https://sid.ir/paper/189369/en

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