A STUDY TO INVESTIGATE ANTIBACTERIAL EFFECT OF NANOCURCUMIN AGAINST PRE-CLINICAL METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION

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ANSARI ELHAM; ISSAZADEH KHOSRO; SHOAE HASANI ALIREZA

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Journal: JOURNAL OF MICROBIAL WORLD Year:2014 | Volume:7 | Issue:1 (18) Page(s): 26-37

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Title

A STUDY TO INVESTIGATE ANTIBACTERIAL EFFECT OF NANOCURCUMIN AGAINST PRE-CLINICAL METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION

Author(s)

ANSARI ELHAM | ISSAZADEH KHOSRO | SHOAE HASANI ALIREZA | Issue Writer Certificate

Keywords

METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUSQ1

NANO-CURCUMINQ1

ANTIBACTERIAL EFFECTQ2

Abstract

Background and Objectives: Bacteremia and endocarditis are the most commonly infection in Staphylococcus aureus. Due to curative effects of curcumin, including as an antibiotic, it can be used as a medicine albeit after reducing its side effects. This study aimed to investigate antimicrobial effects of curcumin on METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS in vitro and in an animal model (Balb/C mice).Materials and Methods: This pre-clinical study was performed in the department of scientific research and clinical technology of Khomeini Hospital, Tehran. Following synthesis of curcumin- PLGA nanoparticles, their size were measured using scanning electron microscopy and their toxicity were determined by a colorimetric method (MTT). In vitro studies to analyze the effects of this compound on MRSA were performed firstly based on MIC and MBC tests and broth dilution. Next, a same procedure was conducted on blood cultures obtained from infected mice.Results: A concentration of 6 micrograms of urcumin-PLGA nanoparticles per millimeter showed Antibacterial activity on MRSA strains. A same effect was observed in vivo in mice after treatment by 10 mg/ml urcumin. Furthermore, based on this results, there were no side effects on the normal cells and 75% of the cells treated with the highest concentration of this particle were survived.Conclusion: these results show that curcumin-PLGA nanoparticles can be used safely for the treatment of bacteremia and endocarditis prophylaxis of infections caused by MRSA.

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APA: Copy

ANSARI, ELHAM, ISSAZADEH, KHOSRO, & SHOAE HASANI, ALIREZA. (2014). A STUDY TO INVESTIGATE ANTIBACTERIAL EFFECT OF NANOCURCUMIN AGAINST PRE-CLINICAL METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION. JOURNAL OF MICROBIAL WORLD, 7(1 (18)), 26-37. SID. https://sid.ir/paper/189402/en

Vancouver: Copy

ANSARI ELHAM, ISSAZADEH KHOSRO, SHOAE HASANI ALIREZA. A STUDY TO INVESTIGATE ANTIBACTERIAL EFFECT OF NANOCURCUMIN AGAINST PRE-CLINICAL METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION. JOURNAL OF MICROBIAL WORLD[Internet]. 2014;7(1 (18)):26-37. Available from: https://sid.ir/paper/189402/en

IEEE: Copy

ELHAM ANSARI, KHOSRO ISSAZADEH, and ALIREZA SHOAE HASANI, “A STUDY TO INVESTIGATE ANTIBACTERIAL EFFECT OF NANOCURCUMIN AGAINST PRE-CLINICAL METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION,” JOURNAL OF MICROBIAL WORLD, vol. 7, no. 1 (18), pp. 26–37, 2014, [Online]. Available: https://sid.ir/paper/189402/en

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