Effect of Retinoic Acid on Ovarian and Oviduct Tissue in Female Adult BALB/c Mice

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Mostaghimi A.; TorabzadehKhorasani P.; RAMEZANI M.

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Journal: JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES) Year:2018 | Volume:11 | Issue:4 (43) Page(s): 1-9

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Title

Effect of Retinoic Acid on Ovarian and Oviduct Tissue in Female Adult BALB/c Mice

Author(s)

Mostaghimi A. | TorabzadehKhorasani P. | RAMEZANI M. | Issue Writer Certificate

Keywords

Retinoic AcidQ3

OvaryQ2

OviductQ1

FollicleQ1

MiceQ2

Abstract

Inroduction & Objective: Retinoic Acid is recognized as regulators of the growth and cell differentiation and is necessary for normal reproductive in male and female. The present study was conducted to investigate the effect of Retinoic Acid on the Ovaries and Oviduct Tissue in Female adult BALB/c Mice Materials and Methods: In this study after determination the appropriate dose of Retinoic Acid, it was injected intraperitoneally (IP) for 30 days On 75 adult BALB/c Mice with doses of 15 (Group I), 25 (Group II), and 35mg/kg. b. w (Group III), control group( non-injection) and sham (distilled water injection). ANOVA analysis and Duncan test was used to compare the means with significant level (P˂ 0. 05) and (P˂ 0. 001). Results: During macroscopic examination, significant weight decrease was observed in all three doses (P <0. 001) and in microscopic studies, reduction of small and large diameter, number of graph Follicles and corpus luteum were observed (P <0. 05), (P <0. 001). While increasing the number of degenerative Follicles and damaged zona pellucidas were significant (P <0. 05), (P <0. 001), and reduction in Oviduct diameter was significantly higher than the control group, of course, this reduction was not significant. Conclusion: It can generally be concluded that Retinoic Acid has a deleterious effect on Ovarian and Oviduct Tissue of Mice

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APA: Copy

Mostaghimi, A., TorabzadehKhorasani, P., & RAMEZANI, M.. (2018). Effect of Retinoic Acid on Ovarian and Oviduct Tissue in Female Adult BALB/c Mice. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), 11(4 (43) ), 1-9. SID. https://sid.ir/paper/191773/en

Vancouver: Copy

Mostaghimi A., TorabzadehKhorasani P., RAMEZANI M.. Effect of Retinoic Acid on Ovarian and Oviduct Tissue in Female Adult BALB/c Mice. JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES)[Internet]. 2018;11(4 (43) ):1-9. Available from: https://sid.ir/paper/191773/en

IEEE: Copy

A. Mostaghimi, P. TorabzadehKhorasani, and M. RAMEZANI, “Effect of Retinoic Acid on Ovarian and Oviduct Tissue in Female Adult BALB/c Mice,” JOURNAL OF ANIMAL PHYSIOLOGY AND DEVELOPMENT (QUARTERLY JOURNAL OF BIOLOGICAL SCIENCES), vol. 11, no. 4 (43) , pp. 1–9, 2018, [Online]. Available: https://sid.ir/paper/191773/en

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