Preparation and characterization of biodegradable magnetic nanoparticles biodegradable based on polyurethane for gene delivery into MCF-7 cells

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Alirezazad Zh.; YAGHOUBI H.; Ajam Z.; JAVID S.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2019 | Volume:11 | Issue:4 Page(s): 45-58

Download Full-Text

Persian Verion

View:

542

Download:

Cites:

Information Journal Paper

Title

Preparation and characterization of biodegradable magnetic nanoparticles biodegradable based on polyurethane for gene delivery into MCF-7 cells

Author(s)

Alirezazad Zh. | YAGHOUBI H. | Ajam Z. | JAVID S. | Issue Writer Certificate

Keywords

Nanoparticle targetingQ1

Drug deliveryQ2

Fe3O4Q1

PEIQ1

PUQ1

PEGQ1

FA nanoparticlesQ1

Abstract

The folate receptor (FR) is known to be over-expressed extracellularly on a variety of human cancers. Therefore, this molecule is an ideal candidate for targeting nanoparticles to Drug delivery using these nanoparticles to cancer cells or cancer tissues. In this study, we designed an amphiphilic cationic Fe3O4-PEI-PU-PEG-FA nanoparticles. The prepared nanoparticles were characterized by FTIR, VSM, TEM measurements. FTIR indicated that the synthesis of Fe3O4-PEI-PU-PEG-FA nanoparticles have been performed successfully. Vibrating sample magnetometry (VSM) showed that the biodegradablemagnetic nanoparticles were superparamagnetic at room temperature. The morphology of the Fe3O4 and Fe3O4-PEI-PU-PEG-FA nanoparticles were evaluated using a transmission electron microscopy. TEM showed the nanoparticles were spherical in shape. Moreover biocompatibility assay of Fe3O4-PEI-PU-PEG-FA nanoparticles was performed using MTT test. Also the ability of Fe3O4-PEI-PUPEG-FA nanoparticles to DNA delivery into MCF-7 cells were analysis using MTT test and flow cytometry respectively. Interestingly, due to the incorporation of PU and PEG segments, this Fe3O4-PEI-PU-PEG-FA nanoparticles showed less toxicity but better gene transfection efficiency than PEI.

Cites

No record.

References

No record.

Cite

APA: Copy

Alirezazad, Zh., YAGHOUBI, H., Ajam, Z., & JAVID, S.. (2019). Preparation and characterization of biodegradable magnetic nanoparticles biodegradable based on polyurethane for gene delivery into MCF-7 cells. JOURNAL OF DEVELOPMENTAL BIOLOGY, 11(4 ), 45-58. SID. https://sid.ir/paper/193172/en

Vancouver: Copy

Alirezazad Zh., YAGHOUBI H., Ajam Z., JAVID S.. Preparation and characterization of biodegradable magnetic nanoparticles biodegradable based on polyurethane for gene delivery into MCF-7 cells. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2019;11(4 ):45-58. Available from: https://sid.ir/paper/193172/en

IEEE: Copy

Zh. Alirezazad, H. YAGHOUBI, Z. Ajam, and S. JAVID, “Preparation and characterization of biodegradable magnetic nanoparticles biodegradable based on polyurethane for gene delivery into MCF-7 cells,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 11, no. 4 , pp. 45–58, 2019, [Online]. Available: https://sid.ir/paper/193172/en

Related Journal Papers