CYTOTOXIC EFFECT OF GIRARD-T REAGENT-BASED SCHIFF BASES AND THEIR DIMETHYLTIN (IV) COMPLEXES ON HUMAN COLON CANCER CELLS

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HOVEIZI ELHAM; ANSARIASL ZYNAB

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Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2018 | Volume:10 | Issue:2 Page(s): 57-65

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Title

CYTOTOXIC EFFECT OF GIRARD-T REAGENT-BASED SCHIFF BASES AND THEIR DIMETHYLTIN (IV) COMPLEXES ON HUMAN COLON CANCER CELLS

Author(s)

HOVEIZI ELHAM | ANSARIASL ZYNAB | Issue Writer Certificate

Keywords

ANTI-CANCERQ1

APOPTOSISQ1

CELL VIABILITYQ2

STEM CELLSQ1

Abstract

Despite many efforts, no definitive treatment is yet knowing for cancer. Therefore, research on new compounds that have ANTI-CANCER properties is especially important. The aim of this study is investigation the cytotoxic effect of Girard-T reagent-based Schiff bases and their complexes on HT29 cancer cells. HT29 cells was cultured in DMEM/F12 medium containing FBS 10% and antibiotics 1% then the effects of ligands and their complexes with the concentration of 0.1, 1 and 5 mg/ml were surveyed on these cells in 1, 2, and 3 days. Growth, proliferation and morphological changes were photographed using an inverted microscope. MTT assay and DAPI staining were used to quantify CELL VIABILITY. With concentrations of 0.1, 1, and 5 mg/ml of [SnMe2 (L2)] (the effective component) the survival were decreased to 34, 24 and 18% after 72h (P<0.05). Encountering cells with complex caused to induce APOPTOSIS in relation with concentration so that, the CELL VIABILITY of cells treated with concentrations of 5 mg/ml (the effective concentration) of (H2L1), (H2L2), [SnMe2 (L1)], [SnMe2 (L2)] was 22, 18, 29, and 22 respectivly after 72h and the highest APOPTOSIS (82%) happened in 5mg/ml of SnMe2 (L2). The synthetic components have a toxic and ant-proliferation effect on HT29 in relation with concentration.

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APA: Copy

HOVEIZI, ELHAM, & ANSARIASL, ZYNAB. (2018). CYTOTOXIC EFFECT OF GIRARD-T REAGENT-BASED SCHIFF BASES AND THEIR DIMETHYLTIN (IV) COMPLEXES ON HUMAN COLON CANCER CELLS. JOURNAL OF DEVELOPMENTAL BIOLOGY, 10(2 ), 57-65. SID. https://sid.ir/paper/193188/en

Vancouver: Copy

HOVEIZI ELHAM, ANSARIASL ZYNAB. CYTOTOXIC EFFECT OF GIRARD-T REAGENT-BASED SCHIFF BASES AND THEIR DIMETHYLTIN (IV) COMPLEXES ON HUMAN COLON CANCER CELLS. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2018;10(2 ):57-65. Available from: https://sid.ir/paper/193188/en

IEEE: Copy

ELHAM HOVEIZI, and ZYNAB ANSARIASL, “CYTOTOXIC EFFECT OF GIRARD-T REAGENT-BASED SCHIFF BASES AND THEIR DIMETHYLTIN (IV) COMPLEXES ON HUMAN COLON CANCER CELLS,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 10, no. 2 , pp. 57–65, 2018, [Online]. Available: https://sid.ir/paper/193188/en

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