The pattern of linkage disequilibrium in three native Iranian sheep breeds

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Barani Somayeh; MORADI SHAHRBABAK MOHAMMAD; NEJATI JAVAREMI ARDESHIR; MORADI MOHAMAD HOSSEIN; GHOLIZADEH MOHSEN; Khansefid Majid

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Animal Science Year:2017 | Volume:48 | Issue:1 Page(s): 11-18

Download Full-Text

Persian Verion

View:

701

Download:

Cites:

Information Journal Paper

Title

The pattern of linkage disequilibrium in three native Iranian sheep breeds

Author(s)

Keywords

BlochiQ1

Genomic selection (GS)Q1

Genome Wide Association Studies (GWAS)Q1

Linkage disequilibriumQ2

Lori-BakhtiarsQ1

ZelQ1

Abstract

Understanding the pattern of Linkage disequilibrium (LD) in different populations provides useful information for genomic selection (GS), genome wide association studies (GWAS) and identification of genetic architecture of traits by estimating the persistence of LD phase between markers and quantitative trait loci (QTL). The aim of this research was to estimate of the extent of LD in three Iranian native sheep breeds. Therefore, 186 blood samples were taken from three sheep breeds (96 Baluchi, 45 lori-Bakhtiari and 45 Zel) and genotyped by Illumina ovine 50K SNPChip, then Linkage disequilibrium in any breed were measured using r2. The results showed that the highest average values of r2 at inter marker distance of less than 10Kb were 0. 392 ± 0. 323, 0. 360± 0. 308 and 0. 340± 0. 306 in Baluchi, Lori-Bakhtiari and Zel, respectively. The highest average values of r2 in autosome chromosomes of each breed were obtained for chromosome 24 and 25 in Baluchi, 9 and 21 in Lori-Bakhtiari and 23 and 24 in Zel. The amount of LD reduced with increasing the distance between markers, the extent of LD was less than 0. 1 at inter marker distances greater than 100Kb. The comparison of correlation coefficients LD between different breeds showed a strong persistence of LD phase between Zel and Lori-Bakhtiari breeds which is probably due to recent common ancestors between these two breeds. Generally, with increase amount of LD means that lower marker density in association studies will be required. The results of this study showed to achieve genomic prediction accuracy of 85% (assuming there is no other accuracy limiting factor) and robust GWAS results, the density of markers must be higher than 50K SNPChip.

Cites

No record.

References

No record.

Cite

APA: Copy

Barani, Somayeh, MORADI SHAHRBABAK, MOHAMMAD, NEJATI JAVAREMI, ARDESHIR, MORADI, MOHAMAD HOSSEIN, GHOLIZADEH, MOHSEN, & Khansefid, Majid. (2017). The pattern of linkage disequilibrium in three native Iranian sheep breeds. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), 48(1 ), 11-18. SID. https://sid.ir/paper/193582/en

Vancouver: Copy

Barani Somayeh, MORADI SHAHRBABAK MOHAMMAD, NEJATI JAVAREMI ARDESHIR, MORADI MOHAMAD HOSSEIN, GHOLIZADEH MOHSEN, Khansefid Majid. The pattern of linkage disequilibrium in three native Iranian sheep breeds. IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES)[Internet]. 2017;48(1 ):11-18. Available from: https://sid.ir/paper/193582/en

IEEE: Copy

Somayeh Barani, MOHAMMAD MORADI SHAHRBABAK, ARDESHIR NEJATI JAVAREMI, MOHAMAD HOSSEIN MORADI, MOHSEN GHOLIZADEH, and Majid Khansefid, “The pattern of linkage disequilibrium in three native Iranian sheep breeds,” IRANIAN JOURNAL OF ANIMAL SCIENCE (IRANIAN JOURNAL OF AGRICULTURAL SCIENCES), vol. 48, no. 1 , pp. 11–18, 2017, [Online]. Available: https://sid.ir/paper/193582/en

Related Journal Papers