ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY OF CEREBELLUM WITH METHYLMERCURY CHLORID POISONING IN NEWBORN RAT

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MORTAZAVI P.; ALTARIHI T.; NAMJOO A.R.

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Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2010 | Volume:7 | Issue:3 Page(s): 307-313

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Title

ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY OF CEREBELLUM WITH METHYLMERCURY CHLORID POISONING IN NEWBORN RAT

Author(s)

MORTAZAVI P. | ALTARIHI T. | NAMJOO A.R. | Issue Writer Certificate

Keywords

METHYLMERCURY CHLORIDEQ3

CEREBELLUMQ3

APOPTOSISQ3

NEWBORN RATQ3

Abstract

Methylmercury (MeHg) is a well-known environment pollutant toxic to the nervous tissue, particularly during development. At a low concentration METHYLMERCURY CHLORIDE (MMC) can be transferred to the fetus through the placenta and to newborn offspring through breast milk. The purposes of this study were to evaluate ultrastructural alteration in the CEREBELLUM of NEWBORN RAT on the 25th postnatal days. Adult Female wistar rats were inoculated with MMC (0.5, 4.5, 10mg/kg /Hg/day) on the 12th, 13th and 14th gestational days. The newborn offspring were placed with the mothers until postnatal day 25. NEWBORN RATs were observed for clinical signs and motor behavior daily. No changes were observed in the clinical signs and motor behavior of these animals. Half of CEREBELLUMs were fixed with 2.5% gluteraldehyde in 0.1 M phosphate buffer and routinely processed for electron microscopy and another sample of CEREBELLUM fixed in formalin buffer 10% solution and processing for paraffin section light microscopy and TUNEL assay test.The component cells of the CEREBELLUM male offspring in the 0.5, 4.5, 10 mg /kg groups showed reduction of granular cells layer and APOPTOSIS in neuron cells.ultrastructural study showed chromatin migration to the edge of nuclei, dilation of the smooth endoplasmic reticulum, ribosomes to shed from the surface of RER. Mitochondria were rounded with condensed matrical spaces and expanded intercristal space. And the matrix was condensed.Our observation confirm that MMC induces neuronal injury and APOPTOSIS in CEREBELLUM.

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APA: Copy

MORTAZAVI, P., ALTARIHI, T., & NAMJOO, A.R.. (2010). ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY OF CEREBELLUM WITH METHYLMERCURY CHLORID POISONING IN NEWBORN RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 7(3), 307-313. SID. https://sid.ir/paper/197326/en

Vancouver: Copy

MORTAZAVI P., ALTARIHI T., NAMJOO A.R.. ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY OF CEREBELLUM WITH METHYLMERCURY CHLORID POISONING IN NEWBORN RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2010;7(3):307-313. Available from: https://sid.ir/paper/197326/en

IEEE: Copy

P. MORTAZAVI, T. ALTARIHI, and A.R. NAMJOO, “ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY OF CEREBELLUM WITH METHYLMERCURY CHLORID POISONING IN NEWBORN RAT,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 7, no. 3, pp. 307–313, 2010, [Online]. Available: https://sid.ir/paper/197326/en

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