HISTOPATHOLOGICAL STUDY OF THE EFFECT OF PENTOXIFYLLINE ON EXPERIMENTAL CHRONIC NONBACTERIAL
PROSTATITIS INDUCED BY CARRAGEENAN IN RAT

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HAJIGHORBANI M.; AHMADI HAMEDANI M.; SHAHAB E.; HAYATI F.; KAFSHDOOZAN K.; GHAFARI KALILI S.; JEBELLI JAVAN A.

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Journal Paper

Paper Information

Journal: JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN Year:2018 | Volume:15 (NEW) | Issue:1 (60) Page(s): 2383-2391

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Title

HISTOPATHOLOGICAL STUDY OF THE EFFECT OF PENTOXIFYLLINE ON EXPERIMENTAL CHRONIC NONBACTERIAL PROSTATITIS INDUCED BY CARRAGEENAN IN RAT

Author(s)

Keywords

CHRONIC NON-BACTERIAL PROSTATITISQ1

HISTOPATHOLOGICAL CRITERIAQ1

PENTOXIFYLLINEQ1

RATQ2

Abstract

Determination of HISTOPATHOLOGICAL CRITERIA of CHRONIC NON-BACTERIAL PROSTATITIS (CNP), as the most common type of prostatitis syndrome, is highly effective to better understanding of pathophysiology and finding therapeutic strategies of this disease. Interest in PENTOXIFYLLINE (PTX) has been renewed because of the anti-inflammatory and antioxidant potential of this drug. The aim of this study was to evaluate HISTOPATHOLOGICAL CRITERIA of CNP in RAT and to investigate the effectiveness of PENTOXIFYLLINE on these criteria. Thirty male adult Wistar RATs were divided into negative control, CNP control, standard and treatment groups. The negative control group received orally 1 ml saline normal for 21 consecutive days CNP was induced by single intraprostatic injection of 1% carrageenan (100 ml) in CNP control, standard and treatment groups. CNP control, standard and treatment groups received orally 1 ml saline normal, cernilton 100 mg/kg and PTX at 50 and 100 mg/kg 1 week after CNP induction for 21 consecutive days. Results showed that in the CNP control group, the PI was significantly increased as compared to negative control group (P<0.01). A significant reduction in the PI was observed in standard and treatment groups, especially PTX 50 mg/kg, in comparison with the CNP control group (P<0.05). Histopathological studies have shown a considerable improvement in the prostatic histoarchitecture in standard and treatment groups, especially PTX 50 mg/kg, in comparison with the CNP control group.

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APA: Copy

HAJIGHORBANI, M., AHMADI HAMEDANI, M., SHAHAB, E., HAYATI, F., KAFSHDOOZAN, K., GHAFARI KALILI, S., & JEBELLI JAVAN, A.. (2018). HISTOPATHOLOGICAL STUDY OF THE EFFECT OF PENTOXIFYLLINE ON EXPERIMENTAL CHRONIC NONBACTERIAL PROSTATITIS INDUCED BY CARRAGEENAN IN RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, 15 (NEW)(1 (60) ), 2383-2391. SID. https://sid.ir/paper/197448/en

Vancouver: Copy

HAJIGHORBANI M., AHMADI HAMEDANI M., SHAHAB E., HAYATI F., KAFSHDOOZAN K., GHAFARI KALILI S., JEBELLI JAVAN A.. HISTOPATHOLOGICAL STUDY OF THE EFFECT OF PENTOXIFYLLINE ON EXPERIMENTAL CHRONIC NONBACTERIAL PROSTATITIS INDUCED BY CARRAGEENAN IN RAT. JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN[Internet]. 2018;15 (NEW)(1 (60) ):2383-2391. Available from: https://sid.ir/paper/197448/en

IEEE: Copy

M. HAJIGHORBANI, M. AHMADI HAMEDANI, E. SHAHAB, F. HAYATI, K. KAFSHDOOZAN, S. GHAFARI KALILI, and A. JEBELLI JAVAN, “HISTOPATHOLOGICAL STUDY OF THE EFFECT OF PENTOXIFYLLINE ON EXPERIMENTAL CHRONIC NONBACTERIAL PROSTATITIS INDUCED BY CARRAGEENAN IN RAT,” JOURNAL OF COMPARATIVE PATHOBIOLOGY IRAN, vol. 15 (NEW), no. 1 (60) , pp. 2383–2391, 2018, [Online]. Available: https://sid.ir/paper/197448/en

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