Protective Effect of Pentoxifylline on Sperm and Biochemical Parameters against Dexamethasone-Induced Toxicity in Mice

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Mahmoodi Monireh; SOLEIMANI MEHRANJANI MALEK; Kheradmand Nasrin

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Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:30 | Issue:185 Page(s): 113-124

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Title

Protective Effect of Pentoxifylline on Sperm and Biochemical Parameters against Dexamethasone-Induced Toxicity in Mice

Author(s)

Mahmoodi Monireh | SOLEIMANI MEHRANJANI MALEK | Kheradmand Nasrin | Issue Writer Certificate

Keywords

dexamethasoneQ3

pentoxifyllineQ2

spermQ2

oxidative stressQ2

miceQ2

Abstract

Background and purpose: Nowadays, the side effects of chemical drugs such as dexamethasone, as a steroidal anti-inflammatory factor, is considered on reducing male reproductive potential. The aim of this study was to evaluate the effect of pentoxifylline on sperm parameters and biochemical factors in mice treated with dexamethasone. Materials and methods: In this study, 24 adult male NMRI mice (35± 2gr) were randomly divided into four groups (n=6 per group): control, dexamethasone (7mg/kg/day), pentoxifylline (200mg/kg/day), and dexamethasone + pentoxifylline. After 7 days of intraperitoneal treatments, sperm parameters and oxidative stress factors were measured. Data were analyzed using one-way analysis of variance (ANOVA) and Tukey’ s test. Results: Compared to the control group, sperm count, progressive motility percentage, viability, sperm tail length (STL), daily sperm production (DSP), and total antioxidant capacity (TAC) significantly decreased in dexamethasone group (P<0. 001), while plasma MDA level showed significant increase (P<0. 001). These parameters did not show significant differences between the control group and the group that received dexamethasone + pentoxifylline (P> 0. 05). Assessment of DNA integrity showed that dexamethasone had no effect on denaturation of the sperm DNA double-stranded structure. Conclusion: According to this study, pentoxifylline could prevent the adverse effects of dexamethasone on sperm parameters, biochemical factors, and daily sperm production by reducing oxidative stress.

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APA: Copy

Mahmoodi, Monireh, SOLEIMANI MEHRANJANI, MALEK, & Kheradmand, Nasrin. (2020). Protective Effect of Pentoxifylline on Sperm and Biochemical Parameters against Dexamethasone-Induced Toxicity in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(185 ), 113-124. SID. https://sid.ir/paper/366451/en

Vancouver: Copy

Mahmoodi Monireh, SOLEIMANI MEHRANJANI MALEK, Kheradmand Nasrin. Protective Effect of Pentoxifylline on Sperm and Biochemical Parameters against Dexamethasone-Induced Toxicity in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(185 ):113-124. Available from: https://sid.ir/paper/366451/en

IEEE: Copy

Monireh Mahmoodi, MALEK SOLEIMANI MEHRANJANI, and Nasrin Kheradmand, “Protective Effect of Pentoxifylline on Sperm and Biochemical Parameters against Dexamethasone-Induced Toxicity in Mice,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 185 , pp. 113–124, 2020, [Online]. Available: https://sid.ir/paper/366451/en

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