A PRODUCTION OF PENTAVALENT CLOSTRIDIAL TOXOID VACCINE AND ITS COMPARISON TO CONVENTIONAL BACTERIN VACCINE

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PILEHCHIAN LANGROUDI R.; JABBARI A.R.; MOOSAWI SHOSHTARY M.; PARDIS A.

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Journal: Veterinary Research & Biological Products Year:2015 | Volume:28 | Issue:1(106) Page(s): 34-42

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Title

A PRODUCTION OF PENTAVALENT CLOSTRIDIAL TOXOID VACCINE AND ITS COMPARISON TO CONVENTIONAL BACTERIN VACCINE

Author(s)

PILEHCHIAN LANGROUDI R. | JABBARI A.R. | MOOSAWI SHOSHTARY M. | PARDIS A. | Issue Writer Certificate

Keywords

PENTAVALENT VACCINEQ2

CLOSTRIDIUMQ2

TOXOIDQ2

FERMENTERQ2

ULTRAFILTARTIONQ1

Abstract

Genus CLOSTRIDIUM, gram positive spore forming anaerobes are very important bacteria for human and animals pathogenesis.Clostridial diseases frequently occurs in Iranian farms and different CLOSTRIDIUM species are responsible for high mortality in domestic animals like as sheep and goats. In the present study, three groups of experimental vaccines were produced and compared to each others. The 1st group as bacterin PENTAVALENT VACCINE was produced in 20 liters glass vessels and adsorbed on aluminium hydroxide adjuvant. The 2nd group as bacterin PENTAVALENT VACCINE has been produced within in 12 liters FERMENTER and adsorbed on aluminium hydroxide adjuvant. Finally, the 3rd group as bacterin-toxoid PENTAVALENT VACCINE was produced in 12 liters FERMENTER and adsorbed on aluminium hydroxide adjuvant. Analysis for freedom from abnormal toxicity, safety and potency tests were performed for all produced vaccine groups. The results showed that the 3rd group of produced vaccine by FERMENTER and purified by ultrafiltration system is the best choice for scaling up.

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APA: Copy

PILEHCHIAN LANGROUDI, R., JABBARI, A.R., MOOSAWI SHOSHTARY, M., & PARDIS, A.. (2015). A PRODUCTION OF PENTAVALENT CLOSTRIDIAL TOXOID VACCINE AND ITS COMPARISON TO CONVENTIONAL BACTERIN VACCINE. VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI), 28(1(106)), 34-42. SID. https://sid.ir/paper/200886/en

Vancouver: Copy

PILEHCHIAN LANGROUDI R., JABBARI A.R., MOOSAWI SHOSHTARY M., PARDIS A.. A PRODUCTION OF PENTAVALENT CLOSTRIDIAL TOXOID VACCINE AND ITS COMPARISON TO CONVENTIONAL BACTERIN VACCINE. VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI)[Internet]. 2015;28(1(106)):34-42. Available from: https://sid.ir/paper/200886/en

IEEE: Copy

R. PILEHCHIAN LANGROUDI, A.R. JABBARI, M. MOOSAWI SHOSHTARY, and A. PARDIS, “A PRODUCTION OF PENTAVALENT CLOSTRIDIAL TOXOID VACCINE AND ITS COMPARISON TO CONVENTIONAL BACTERIN VACCINE,” VETERINARY RESEARCHES BIOLOGICAL PRODUCTS (PAJOUHESH-VA-SAZANDEGI), vol. 28, no. 1(106), pp. 34–42, 2015, [Online]. Available: https://sid.ir/paper/200886/en

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