EFFECT OF HYPERICUM PERFORATUM EXTRACT ON CONSOLIDATION OF PASSIVE AVOIDANCE LEARNING OF ACUTELY RESTRAINED MALE WISTAR RATS

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ASADI PARVIN; ROSHANAE KAMBIZ; MOHAJERANI HAMID REZA

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2014 | Volume:4 | Issue:13 Page(s): 51-56

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Title

EFFECT OF HYPERICUM PERFORATUM EXTRACT ON CONSOLIDATION OF PASSIVE AVOIDANCE LEARNING OF ACUTELY RESTRAINED MALE WISTAR RATS

Author(s)

ASADI PARVIN | ROSHANAE KAMBIZ | MOHAJERANI HAMID REZA | Issue Writer Certificate

Keywords

HYPERICUM EXTRACTQ2

PASSIVE AVOIDANCE LEARNINGQ2

MEMORYQ2

ACUTE IMMOBILITY STRESSQ2

RATQ2

SHUTTLE BOXQ2

Abstract

Aim and Background: Ageing may result in increase of oxidative stress that in turn might lead to the damage of brain processes including cognitive functions. Since HYPERICUM EXTRACT have decreasing effect on the stress, its effect on PASSIVE AVOIDANCE LEARNING of restrained male wistar RATs was examined.Materials and methods: Twenty-four male wistar RATs, each weighing about 250-300 g were divided into four groups, control, immobility stress , immobility stress + HYPERICUM EXTRACT (animals administered with 350 mg/kg/day of HYPERICUM EXTRACT) and HYPERICUM EXTRACT group. All the groups had free access to water and food with no limitation. HYPERICUM EXTRACT was administrated orally as soluted in water each day for one week. The PASSIVE AVOIDANCE LEARNING test was done in the SHUTTLE BOX device following intending treatments for all groups and in similar conditions. In this test, increased time delay for the first time of entry to the dark chamber considered as improved PASSIVE AVOIDANCE LEARNING. The data were then analyzed by SPSS software and one-way ANOVA followed by the Tuckey test.Results: Compared to the control group, passive avoidance indices were increased significantly. In other words, mean Step Through Latency (STL) of H. perforatum + stress group was 207 seconds and higher than that of stress only group (150 seconds) significantly (p<.001). The maximum acceptable for STL was considered as 300 seconds.Conclusion: Our results indicated that administered HYPERICUM EXTRACT could increase PASSIVE AVOIDANCE LEARNING indices in RATs in the model of immobility stress of male wistar RATs.

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APA: Copy

ASADI, PARVIN, ROSHANAE, KAMBIZ, & MOHAJERANI, HAMID REZA. (2014). EFFECT OF HYPERICUM PERFORATUM EXTRACT ON CONSOLIDATION OF PASSIVE AVOIDANCE LEARNING OF ACUTELY RESTRAINED MALE WISTAR RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 4(13), 51-56. SID. https://sid.ir/paper/204374/en

Vancouver: Copy

ASADI PARVIN, ROSHANAE KAMBIZ, MOHAJERANI HAMID REZA. EFFECT OF HYPERICUM PERFORATUM EXTRACT ON CONSOLIDATION OF PASSIVE AVOIDANCE LEARNING OF ACUTELY RESTRAINED MALE WISTAR RATS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2014;4(13):51-56. Available from: https://sid.ir/paper/204374/en

IEEE: Copy

PARVIN ASADI, KAMBIZ ROSHANAE, and HAMID REZA MOHAJERANI, “EFFECT OF HYPERICUM PERFORATUM EXTRACT ON CONSOLIDATION OF PASSIVE AVOIDANCE LEARNING OF ACUTELY RESTRAINED MALE WISTAR RATS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 4, no. 13, pp. 51–56, 2014, [Online]. Available: https://sid.ir/paper/204374/en

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