STUDY THE EFFECT OF ENDOCANNABINOID, CHOLINERGIC SYSTEM AND BOTH OF THEM ON THE MEMORY MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHIDI SIAMAK; TOUSAN TAYEBE; KAZEMEINI FATEMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2017 | Volume:7 | Issue:27 Page(s): 25-32

Download Full-Text

Persian Verion

View:

567

Download:

Cites:

Information Journal Paper

Title

STUDY THE EFFECT OF ENDOCANNABINOID, CHOLINERGIC SYSTEM AND BOTH OF THEM ON THE MEMORY MICE

Author(s)

SHAHIDI SIAMAK | TOUSAN TAYEBE | KAZEMEINI FATEMEH | Issue Writer Certificate

Keywords

CANNABINOIDSQ1

CHOLINERGIC SYSTEMQ1

MEMORYQ2

MICEQ2

Abstract

Aim and Background: CANNABINOIDS are known to attenuate MEMORY in both humans and animals that effects of this compounds act through their receptors. These compounds can affect on the MEMORY and learning through the hippocampus. Acetylcholine, as a neurotransmitter, plays fundamental role during process of learning and MEMORY and donepezil can be potentiation effect in cholinergic synapse On this material. In this research the effects of donepezil, URB597 “potentiation endocannabinoid system " and effect of both them on the MEMORY in MICE was investigated.Materials and Methods: In this experimental research 40 male MICE weighting 20-35 g were divided to the 4 groups including control, URB597 (0.1 mg/kg, i.p), donepezil (0.5 mg/kg, i.p.) and URB597 & donepezil. MICE to the first day received in the Shuttle box electrical trial then at the second day intraperitoneal administrate of drugs 15 minutes before the retrieval test. Two analysis parameters, delay the first time in the dark chamber (STLr) and sum of to remain time in the dark chamber (TDC).Result: Analysis of data indicated, that there was not significant difference in received number of trials. But there was significant difference between groups control and URB597 (p<0.001) in STLr. Also there was significant difference URB597 (p<0.001) in comparison by control and compound URB597 & donepezil groups in TDC and also there was significant difference in compound URB597 & donepezil (p<0.005) group in comparison to control group.Conclusion: Result of this experiment shown that URB597 led to MEMORY impairment and administration of donepezil, as CHOLINERGIC SYSTEM potentiation, has improvement affect on the destructitive MEMORY, so indicate interference of both system led to MEMORY reinforcement.

Cites

Comparison of Alphapinene and Donpezil Effects on Passive Avoidance Memory in Adult Male Rats

References

No record.

Cite

APA: Copy

SHAHIDI, SIAMAK, TOUSAN, TAYEBE, & KAZEMEINI, FATEMEH. (2017). STUDY THE EFFECT OF ENDOCANNABINOID, CHOLINERGIC SYSTEM AND BOTH OF THEM ON THE MEMORY MICE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 7(27 ), 25-32. SID. https://sid.ir/paper/204482/en

Vancouver: Copy

SHAHIDI SIAMAK, TOUSAN TAYEBE, KAZEMEINI FATEMEH. STUDY THE EFFECT OF ENDOCANNABINOID, CHOLINERGIC SYSTEM AND BOTH OF THEM ON THE MEMORY MICE. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2017;7(27 ):25-32. Available from: https://sid.ir/paper/204482/en

IEEE: Copy

SIAMAK SHAHIDI, TAYEBE TOUSAN, and FATEMEH KAZEMEINI, “STUDY THE EFFECT OF ENDOCANNABINOID, CHOLINERGIC SYSTEM AND BOTH OF THEM ON THE MEMORY MICE,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 7, no. 27 , pp. 25–32, 2017, [Online]. Available: https://sid.ir/paper/204482/en

Related Journal Papers