A REVIEW OF METHODS FOR THE PRODUCTION OF THERAPEUTIC RECOMBINANT PROTEINS IN PICHIA PASTORIS

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BABAVALIAN HAMID; LATIFI ALI MOHAMMAD; AMANI JAFAR; SADEGH NEJAD EHSAN; SHAKERI FATEMEH

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2014 | Volume:4 | Issue:14 Page(s): 9-24

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Title

A REVIEW OF METHODS FOR THE PRODUCTION OF THERAPEUTIC RECOMBINANT PROTEINS IN PICHIA PASTORIS

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Keywords

PICHIA PASTORISQ2

RECOMBINANT PROTEINQ2

EXPRESSION SYSTEMSQ1

Abstract

Yeast EXPRESSION SYSTEMS have produced RECOMBINANT PROTEINs for more than 20 years having proven to be efficient in production of pharmaceutical metabolites. The methylotrophic yeast PICHIA PASTORIS has been widely reported as a suitable host cell for expression of RECOMBINANT PROTEINs which has been dramatically used in recent years in pharmaceutical industry. Expression system of PICHIA PASTORIS has more advantages including easy genetic manipulation, high cell densities than mammalian cells, high potential for the production of RECOMBINANT PROTEIN with post-translational modifications, strong promoters for expression of RECOMBINANT PROTEIN and transformation of DNA external containing multiple copies of a target protein through homologous recombination process that they can be efficient for wide application in industrial fields. In this review, we investigated the system characteristics of PICHIA PASTORIS yeast through genetic engineering, protein chemistry and molecular design that are necessary for the expression of the target proteins.

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APA: Copy

BABAVALIAN, HAMID, LATIFI, ALI MOHAMMAD, AMANI, JAFAR, SADEGH NEJAD, EHSAN, & SHAKERI, FATEMEH. (2014). A REVIEW OF METHODS FOR THE PRODUCTION OF THERAPEUTIC RECOMBINANT PROTEINS IN PICHIA PASTORIS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 4(14), 9-24. SID. https://sid.ir/paper/204541/en

Vancouver: Copy

BABAVALIAN HAMID, LATIFI ALI MOHAMMAD, AMANI JAFAR, SADEGH NEJAD EHSAN, SHAKERI FATEMEH. A REVIEW OF METHODS FOR THE PRODUCTION OF THERAPEUTIC RECOMBINANT PROTEINS IN PICHIA PASTORIS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2014;4(14):9-24. Available from: https://sid.ir/paper/204541/en

IEEE: Copy

HAMID BABAVALIAN, ALI MOHAMMAD LATIFI, JAFAR AMANI, EHSAN SADEGH NEJAD, and FATEMEH SHAKERI, “A REVIEW OF METHODS FOR THE PRODUCTION OF THERAPEUTIC RECOMBINANT PROTEINS IN PICHIA PASTORIS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 4, no. 14, pp. 9–24, 2014, [Online]. Available: https://sid.ir/paper/204541/en

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