EXPRESSION OF CD-34, OCT-4 AND BRACHYURY GENES OF CARDIOMYOCYTES DERIVED FROM HUMAN EMBRYONIC STEM CELLS

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TABATABAEI PANAH AKRAM SADAT; AKBARZADEH REZA

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Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2017 | Volume:7 | Issue:25 Page(s): 117-123

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Title

EXPRESSION OF CD-34, OCT-4 AND BRACHYURY GENES OF CARDIOMYOCYTES DERIVED FROM HUMAN EMBRYONIC STEM CELLS

Author(s)

TABATABAEI PANAH AKRAM SADAT | AKBARZADEH REZA | Issue Writer Certificate

Keywords

CARDIOMYOCYTESQ2

EMBRYOID BODIESQ2

GENE EXPRESSIONQ1

HUMAN EMBRYONIC STEMQ2

Abstract

Aim and Background: CARDIOMYOCYTES derived from HUMAN EMBRYONIC STEM cells (hESCs) could be useful in restoring heart function after myocardial infarction or in heart failure. The hESCs can differentiatein vitro into spontaneously contracting CARDIOMYOCYTES and produce a model to investigate the early developmental stages of this system. After removing of cells from their feeder layer, hESCs create EMBRYOID BODIES (EB). Plating of EB result in developing areas of beating cells.Materials and Methods: After stem cell culture, cardiomyocyte’s mRNA extracted in different time after differentiation. The expression pattern CD-34, OCT-4 and Brachyury were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR).Results: There was an enhanced expression of as CD-34 from day 21 in EB in suspension. The OCT-4gene expression was in 5-day-old EB and Brachyury expression was significantly increased by day 21.Conclusion: hESCs might be useful as an effective model system for understanding the developmental processes and functioning of the human heart.

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APA: Copy

TABATABAEI PANAH, AKRAM SADAT, & AKBARZADEH, REZA. (2017). EXPRESSION OF CD-34, OCT-4 AND BRACHYURY GENES OF CARDIOMYOCYTES DERIVED FROM HUMAN EMBRYONIC STEM CELLS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 7(25), 117-123. SID. https://sid.ir/paper/204599/en

Vancouver: Copy

TABATABAEI PANAH AKRAM SADAT, AKBARZADEH REZA. EXPRESSION OF CD-34, OCT-4 AND BRACHYURY GENES OF CARDIOMYOCYTES DERIVED FROM HUMAN EMBRYONIC STEM CELLS. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2017;7(25):117-123. Available from: https://sid.ir/paper/204599/en

IEEE: Copy

AKRAM SADAT TABATABAEI PANAH, and REZA AKBARZADEH, “EXPRESSION OF CD-34, OCT-4 AND BRACHYURY GENES OF CARDIOMYOCYTES DERIVED FROM HUMAN EMBRYONIC STEM CELLS,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 7, no. 25, pp. 117–123, 2017, [Online]. Available: https://sid.ir/paper/204599/en

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