SENSITIVITY DETERMINATION OF ASPERGILUS FLAVUS TO ITRACONAZOL, VORICONAZOL AND CASPOFUNGIN

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HOJATINIA HAMID; SABOKBAR AZAR

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Paper Information

Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2016 | Volume:6 | Issue:22 Page(s): 51-58

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Title

SENSITIVITY DETERMINATION OF ASPERGILUS FLAVUS TO ITRACONAZOL, VORICONAZOL AND CASPOFUNGIN

Author(s)

HOJATINIA HAMID | SABOKBAR AZAR | Issue Writer Certificate

Keywords

ASPERGILLUS FLAVUSQ2

DRUG SENSITIVITYQ2

ITRACONAZOLQ1

VORICONAZOLQ1

CASPOFUNGINENEWQ1

Abstract

Aims and Background: Different studies have shown that despite the expanding number of antifungal agents, death rate caused by Aspergillus species has been increased during the recent decades due to drug-resistance occurrence, increased minimum inhibitory concentration (MIC) and cross-resistance among the isolated species. Regarding the lack of effective response to conventional treatments and antifungal susceptibility patterns of the most common isolated Aspergillus species.Material and methods: In this study, during 9 months; 20 clinical isolates and 20 environmental strains were studied. In the next stage, DRUG SENSITIVITY test was done according to the NCCLS-M38P method. A fungal suspension was made with 1-4*104 cfu/ml cellular range using 530nm spectrophotometer. Serial dilution of ITRACONAZOL, VORICONAZOL (0.015-16mg/ml) and Caspofungin (0.007-8mg/ml) were performed and MIC was determined after 48Hr of incubation on 35oc.Results: In studied strains we did not find any drug resistance gene. MIC range for ASPERGILLUS FLAVUS in ITRACONAZOL was determined as 0.125-2 mg/ml which MIC50= 0.5 and MIC90=1mg/ml. also for vericonazol range was 0.25-2 mg/ml and MIC 50=0.5 and MIC90=1 determined and caspofungin 0.0131-0.125 mg/ml and MIC50=0.063 and MIC50=0.063 and MIC90=0.125.Conclusion: According to MIC range for ITRACONAZOL, VORICONAZOL and caspofungin, the studied ASPERGILLUS FLAVUS strains were drug sensitive; also, we did not find any drug resistance strain.

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APA: Copy

HOJATINIA, HAMID, & SABOKBAR, AZAR. (2016). SENSITIVITY DETERMINATION OF ASPERGILUS FLAVUS TO ITRACONAZOL, VORICONAZOL AND CASPOFUNGIN. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 6(22), 51-58. SID. https://sid.ir/paper/204628/en

Vancouver: Copy

HOJATINIA HAMID, SABOKBAR AZAR. SENSITIVITY DETERMINATION OF ASPERGILUS FLAVUS TO ITRACONAZOL, VORICONAZOL AND CASPOFUNGIN. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2016;6(22):51-58. Available from: https://sid.ir/paper/204628/en

IEEE: Copy

HAMID HOJATINIA, and AZAR SABOKBAR, “SENSITIVITY DETERMINATION OF ASPERGILUS FLAVUS TO ITRACONAZOL, VORICONAZOL AND CASPOFUNGIN,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 6, no. 22, pp. 51–58, 2016, [Online]. Available: https://sid.ir/paper/204628/en

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