ANALYSIS OF A SUITABLE MODEL FOR THE STUDY OF ATHEROSCLEROSIS IN INSULIN DEPENDENT DIABETES

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VALIAN BROJENI S.; MADANI H.; NAGHSH N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2002 | Volume:12 | Issue:1-2 Page(s): 21-27

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Title

ANALYSIS OF A SUITABLE MODEL FOR THE STUDY OF ATHEROSCLEROSIS IN INSULIN DEPENDENT DIABETES

Author(s)

VALIAN BROJENI S. | MADANI H. | NAGHSH N. | Issue Writer Certificate

Keywords

DIABETES; ATHEROSCLEROSIS; ALLOXAN; TRIACYLGLYCEROL; CHOLESTEROLQ2

Abstract

Atherosclerosis is one of the coronary-heart diseases which is associated with diabetes. The metabolism of lipids and carbohydrates is alerted in atherosclerosis and diabetes. Therefore, an appropriate animal model could be useful in analyzing the mechanisms involoved in the initiation of atherosclerosis in diabetes. In this study, the atherosclerosis indices were analyzed in rat following induction of diabetes using. Alloxan monohydrate. Examination of low density lipoprotein (LDL) in diabetic animals showed a marked increase compare with control group (p =0.007). Analysis .of plasma high density lipoprotein (HDL) as another factor involved in atherosclerosis, demonstrated a sharp in diabetic animals compared to the control group (p =0). Furthermore, analysis of the concentration of triacylglycerol in plasma indicated a significant increase in diabetic condition compared to the normal condition in control groups. In contrast, the plasma cholestrol level did not show any significant changes, which could be related to the self regulatory mechanisms controlling its plasma concentration. Examination of the weight of the spleen showed an increase in diabetic animals compared to the control group, suggesting the presence of increased stimulation of the immune system. This indicated that atherosclerosis was associated with autoimmunity. Together, the data from this study suggested that diabetes induced by Alloxan could .be used as an animal model for studying the mechanisms involved in atherosclerosis.

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APA: Copy

VALIAN BROJENI, S., MADANI, H., & NAGHSH, N.. (2002). ANALYSIS OF A SUITABLE MODEL FOR THE STUDY OF ATHEROSCLEROSIS IN INSULIN DEPENDENT DIABETES. IRANIAN JOURNAL OF BIOLOGY, 12(1-2), 21-27. SID. https://sid.ir/paper/21174/en

Vancouver: Copy

VALIAN BROJENI S., MADANI H., NAGHSH N.. ANALYSIS OF A SUITABLE MODEL FOR THE STUDY OF ATHEROSCLEROSIS IN INSULIN DEPENDENT DIABETES. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2002;12(1-2):21-27. Available from: https://sid.ir/paper/21174/en

IEEE: Copy

S. VALIAN BROJENI, H. MADANI, and N. NAGHSH, “ANALYSIS OF A SUITABLE MODEL FOR THE STUDY OF ATHEROSCLEROSIS IN INSULIN DEPENDENT DIABETES,” IRANIAN JOURNAL OF BIOLOGY, vol. 12, no. 1-2, pp. 21–27, 2002, [Online]. Available: https://sid.ir/paper/21174/en

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