COMPARISON OF THE EFFECTS OF HARMALA ALKALOIDS ON BODY TEMPERATURE IN MICE

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KIANBAKHT S.; MOBASHERI T.; MAHMOUDIAN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Applied Biology Year:2000 | Volume:13 | Issue:1 Page(s): 1-10

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Title

COMPARISON OF THE EFFECTS OF HARMALA ALKALOIDS ON BODY TEMPERATURE IN MICE

Author(s)

KIANBAKHT S. | MOBASHERI T. | MAHMOUDIAN M. | Issue Writer Certificate

Keywords

(1) HARMALA ALKALOIDSQ4

(2) BETA-CARBOLINESQ4

(3) BODY TEMPERATUREQ4

(4) MICEQ4

Abstract

Harmine, Harmaline, Harmane and norharmane are a group of B-carboline alkaloids of Peganum harmala L. Harmane and norharmane are of special interest because they are found endogenously in mammalian tissues. In this study, the effects of the alkaloids on body temperature in mice were compared and by using the benzodiazepine receptors antagonist flumazenil, the role of benzodianzepine receptors in these effects was investigated. Since locomotor activity may affect temperature control in mice, the effects of these compounds on locomotion were also assessed at the same doses and conditions that influenced body temperature. The studies were carried out on mice by using harmine, harmaline, harmane, norharmane and flumazenil. Body temperature was measured by putting a probe into the animal anus and locomotor activity was measured by using an activity meter with two ultrasonic transducers. Harmine (0.5, 1.5, 2.5,5 mg/kg i.p.), harmaline (0.5, 1.5, 2.5, 5 mg/kg i.p.), harmane (0.5, 1, 2, 4 mg/kg i.p.) and norharmane (0.5, 1, 2, 4 mg/kg i.p.) reduced body temperature dose dependently, but did not affect locomotor activity. Differences between the body temperature lowering efficacies of the alkaloids were not significant, however hamane was significantly more potent than the other alkaloids (P<0.05). Flumazenil did not antagonize the body temperature lowering effects of the alkaloids. The harmala alkaloids reduce body temperature in mice dose dependently at doses that do not affect locomotor activity. It seems that benzodiazpine receptors are not involved in the hypothermic effects of the alkaloids.

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APA: Copy

KIANBAKHT, S., MOBASHERI, T., & MAHMOUDIAN, M.. (2000). COMPARISON OF THE EFFECTS OF HARMALA ALKALOIDS ON BODY TEMPERATURE IN MICE. JOURNAL OF APPLIED BIOLOGY (JOURNAL OF SCIENCE), 13(1), 1-10. SID. https://sid.ir/paper/22692/en

Vancouver: Copy

KIANBAKHT S., MOBASHERI T., MAHMOUDIAN M.. COMPARISON OF THE EFFECTS OF HARMALA ALKALOIDS ON BODY TEMPERATURE IN MICE. JOURNAL OF APPLIED BIOLOGY (JOURNAL OF SCIENCE)[Internet]. 2000;13(1):1-10. Available from: https://sid.ir/paper/22692/en

IEEE: Copy

S. KIANBAKHT, T. MOBASHERI, and M. MAHMOUDIAN, “COMPARISON OF THE EFFECTS OF HARMALA ALKALOIDS ON BODY TEMPERATURE IN MICE,” JOURNAL OF APPLIED BIOLOGY (JOURNAL OF SCIENCE), vol. 13, no. 1, pp. 1–10, 2000, [Online]. Available: https://sid.ir/paper/22692/en

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