Design and Preparation of Photoluminescent Nanoparticles based on Chimeric Peptides-Graphene Quantum Dots for Nuclear Drug Delivery and Tracking

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MOASSES GHAFARY S.; NIKKHAH M.; Hatamie Sh.; HOSSEINKHANI S.

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Journal: JOURNAL OF BIOTECHNOLOGY Year:2019 | Volume:10 | Issue:1 Page(s): 45-51

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Title

Design and Preparation of Photoluminescent Nanoparticles based on Chimeric Peptides-Graphene Quantum Dots for Nuclear Drug Delivery and Tracking

Author(s)

MOASSES GHAFARY S. | NIKKHAH M. | Hatamie Sh. | HOSSEINKHANI S. | Issue Writer Certificate

Keywords

Graphene Quantum DotsQ1

Chimeric PeptideQ1

BioimagingQ1

TrackingQ2

Abstract

One of the main challenges in the treatment of genetic disorders, such as cancer, is inefficiency of drug delivery systems and their inability to monitor and track delivered drug to the targeted site. Therefore, the design of novel nanocarriers with dual capabilities of nuclear drug delivery and Tracking have recently turned into a research priority for this field’ s scholars. The aim of this study is to design photoluminescence nanostructures based on both non-cytotoxic Graphene Quantum Dots and Chimeric Peptides, with dual capabilities namely Tracking and delivering small genetic agents into the nucleus. The GQDs with green emission color were synthesized by Hummer’ s and solvothermal methods and characterized by UV-Vis, photoluminescence (PL), Raman spectroscopies, and scanning electron microscopy (SEM). GQDs were conjugated with MPG-2H1 Chimeric Peptides through noncovalent interactions. Following conjugation step, the ζ-potential of the complex increased (From-38. 6 to-11. 1 in complex1,-9. 6 in complex2 and-5. 74 in complex3). The conjugation was confirmed by native acrylamide gel retardation assay. The cytotoxicity of the GQDs was investigated by MTT assay and finally, Bioimaging was carried out. The results showed that MPG-2H1/ GQD complexes can enter cells; however, free-GQDs didn’ t enter the cells significantly.

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APA: Copy

MOASSES GHAFARY, S., NIKKHAH, M., Hatamie, Sh., & HOSSEINKHANI, S.. (2019). Design and Preparation of Photoluminescent Nanoparticles based on Chimeric Peptides-Graphene Quantum Dots for Nuclear Drug Delivery and Tracking. JOURNAL OF BIOTECHNOLOGY, 10(1 ), 45-51. SID. https://sid.ir/paper/231234/en

Vancouver: Copy

MOASSES GHAFARY S., NIKKHAH M., Hatamie Sh., HOSSEINKHANI S.. Design and Preparation of Photoluminescent Nanoparticles based on Chimeric Peptides-Graphene Quantum Dots for Nuclear Drug Delivery and Tracking. JOURNAL OF BIOTECHNOLOGY[Internet]. 2019;10(1 ):45-51. Available from: https://sid.ir/paper/231234/en

IEEE: Copy

S. MOASSES GHAFARY, M. NIKKHAH, Sh. Hatamie, and S. HOSSEINKHANI, “Design and Preparation of Photoluminescent Nanoparticles based on Chimeric Peptides-Graphene Quantum Dots for Nuclear Drug Delivery and Tracking,” JOURNAL OF BIOTECHNOLOGY, vol. 10, no. 1 , pp. 45–51, 2019, [Online]. Available: https://sid.ir/paper/231234/en

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