Preparation of Carboxymethyl Cellulose/Calcium Alginate/ Polyvinyl Alcohol/Silver Nanocomposite by Electrospinning Method and Its Performance as Wound Dressing

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FARBODI M.; Khoshkbar Sadeghi A.R.

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Journal: JOURNAL OF BIOTECHNOLOGY Year:2018 | Volume:9 | Issue:4 Page(s): 593-601

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Title

Preparation of Carboxymethyl Cellulose/Calcium Alginate/ Polyvinyl Alcohol/Silver Nanocomposite by Electrospinning Method and Its Performance as Wound Dressing

Author(s)

FARBODI M. | Khoshkbar Sadeghi A.R. | Issue Writer Certificate

Keywords

Carboxymethyl CelluloseQ1

Calcium AlginateQ2

Polyvinyl AlcoholQ1

SilverQ2

ElectrospiningQ1

AntibacterialQ1

Abstract

Aims In medicine, nanofiber can be used in wound dressing. The aim of this study was to prepare Carboxymethyl Cellulose/Calcium Alginate/Polyvinyl Alcohol/Silver (CMC/Alg/PVA/ Ag) nanocomposite by electrospinning method and to investigate its performance as wound dressing. Materials & Methods In the present experimental study, CMC biofilm was prepared by solution method. Then, Calcium Alginate/Polyvinyl Alcohol/Silver (Alg/PVA/Ag) nanofiber was prepared by Electrospining method in the optimal conditions and deposited on CMC film. Finally, the possibleof application of the product as wound dressing and its Antibacterial and morphological properties, as well as permeability to water vapor were investigated. Findings CMC/Alg/PVA/Ag film had more permeability in comparison to Alg/PVA/Ag nanofibers and less water vapor permeability value in comparison to CMC film. The most sensivity belonged to Escherichia coli and Klebsiella pneumoniae gram-negative bacteria with inhibition zone diameter of 23mm and 24mm, respectively, and Staphylococcus aureus and Staphylococcus saprophyticus gram-positive bacteria with inhibition zone diameter of 21mm and 17mm, respectively, for CMC/Alg/PVA/Ag film. Also, the wound with CMC/Alg/PVA/Ag dressing significantly showed more healing speed in comparison to CMC dressings and CMC/ Ag. Conclusion The use of CMC/Alg/PVA/Ag nanocomposite as wound dressing is possible. This dressing, with pores, allows the vapors to flow through the wound secretions, is impermeable to liquids and bacteria, but is permeable to oxygen and vapor; it is not allergenic and does not cause toxicity and chemical stimulation, transparent dressing and the possibility of seeing the wound is easily possible, it provides the moisture level needed for wound healing, it does not stick to the wound and as a result, its replacement is without pain and cheap.

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APA: Copy

FARBODI, M., & Khoshkbar Sadeghi, A.R.. (2018). Preparation of Carboxymethyl Cellulose/Calcium Alginate/ Polyvinyl Alcohol/Silver Nanocomposite by Electrospinning Method and Its Performance as Wound Dressing. JOURNAL OF BIOTECHNOLOGY, 9(4 ), 593-601. SID. https://sid.ir/paper/231305/en

Vancouver: Copy

FARBODI M., Khoshkbar Sadeghi A.R.. Preparation of Carboxymethyl Cellulose/Calcium Alginate/ Polyvinyl Alcohol/Silver Nanocomposite by Electrospinning Method and Its Performance as Wound Dressing. JOURNAL OF BIOTECHNOLOGY[Internet]. 2018;9(4 ):593-601. Available from: https://sid.ir/paper/231305/en

IEEE: Copy

M. FARBODI, and A.R. Khoshkbar Sadeghi, “Preparation of Carboxymethyl Cellulose/Calcium Alginate/ Polyvinyl Alcohol/Silver Nanocomposite by Electrospinning Method and Its Performance as Wound Dressing,” JOURNAL OF BIOTECHNOLOGY, vol. 9, no. 4 , pp. 593–601, 2018, [Online]. Available: https://sid.ir/paper/231305/en

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