AN INVESTIGATION INTO THE EFFECT OF MORUS NIGRA L. LEAF EXTRACT ON PARKINSON'S DISEASE SYMPTOMS AND OXIDATIVE STRESS MARKERS IN MALE RATS

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NASRI S.; NIKNAMI Z.; ZIAI S.A.; ROGHANI M.; KAMALINEJAD M.

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Journal: JOURNAL OF VETERINARY CLINICAL RESEARCH Year:2012 | Volume:3 | Issue:3 (11) Page(s): 129-141

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Title

AN INVESTIGATION INTO THE EFFECT OF MORUS NIGRA L. LEAF EXTRACT ON PARKINSON'S DISEASE SYMPTOMS AND OXIDATIVE STRESS MARKERS IN MALE RATS

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Keywords

PARKINSON’S DISEASEQ2

DOPAMINEQ2

MORUS NIGRAQ2

OXIDATIVE STRESSQ2

ACEQ2

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder. In this disease, decrease activity of DOPAMINErgic neurons in the substantia nigra and DOPAMINE level in the striatum. There is much evidence in effect of OXIDATIVE STRESS as pathogen agents of PARKINSON’S DISEASE progression. Angiotensin II activates NADPH depending oxidases and produce superoxides formation. MORUS NIGRA L. extract shows good Angiotensin Converting Enzyme (ACE) inhibitory effects, in Vitro. The aim of this study is to study the antioxidant effects of MORUS NIGRA L. leaf extract on PARKINSON’S DISEASE symptoms and OXIDATIVE STRESS markers. 48 male rats divided randomly into four groups (n=12 each): I) sham, (2) toxin, (3) captopril, (4) treatment. Rats in sham group were used as normal controls. Rats in toxin group were injected with 6-0HDA. Captopril group were injected i.p. with Captopril (5 mg/kg) daily 6 days before and 4 & 24 hrs after the injection of 6-0HDA and treatment group were injected i.p. with MORUS NIGRA L. (10 mglkg) extract daily 6 days before the injection of 6-0HDA in the substantia nigra and 4 & 24 hrs after it. Muscle stiffness, rotation test and histological test were assessed in 6 rats of any groups after 2 weeks. Protein oxidation, lipid peroxidation and ACE activity were assessed in brain in 6 rats of any groups 24 hrs, after the 6-0HDA injection. The results suggested that the use of aqueous extract of MORUS NIGRA can be useful in reduction of PARKINSON’S DISEASE symptoms and reduce OXIDATIVE STRESS markers and DOPAMINErgic neuronal death.

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APA: Copy

NASRI, S., NIKNAMI, Z., ZIAI, S.A., ROGHANI, M., & KAMALINEJAD, M.. (2012). AN INVESTIGATION INTO THE EFFECT OF MORUS NIGRA L. LEAF EXTRACT ON PARKINSON'S DISEASE SYMPTOMS AND OXIDATIVE STRESS MARKERS IN MALE RATS. JOURNAL OF VETERINARY CLINICAL RESEARCH, 3(3 (11)), 129-141. SID. https://sid.ir/paper/233004/en

Vancouver: Copy

NASRI S., NIKNAMI Z., ZIAI S.A., ROGHANI M., KAMALINEJAD M.. AN INVESTIGATION INTO THE EFFECT OF MORUS NIGRA L. LEAF EXTRACT ON PARKINSON'S DISEASE SYMPTOMS AND OXIDATIVE STRESS MARKERS IN MALE RATS. JOURNAL OF VETERINARY CLINICAL RESEARCH[Internet]. 2012;3(3 (11)):129-141. Available from: https://sid.ir/paper/233004/en

IEEE: Copy

S. NASRI, Z. NIKNAMI, S.A. ZIAI, M. ROGHANI, and M. KAMALINEJAD, “AN INVESTIGATION INTO THE EFFECT OF MORUS NIGRA L. LEAF EXTRACT ON PARKINSON'S DISEASE SYMPTOMS AND OXIDATIVE STRESS MARKERS IN MALE RATS,” JOURNAL OF VETERINARY CLINICAL RESEARCH, vol. 3, no. 3 (11), pp. 129–141, 2012, [Online]. Available: https://sid.ir/paper/233004/en

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