COMPARISON OF THE EFFECTS OF OMPERAZOLE AND RABEPRAZOLE IN PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN RATS

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REZVANJOO B.; BAGHAIKIA A.; MOAYER F.; GHAFARI M.; SHIRAZI BEHESHTIHA S.H.

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Journal: JOURNAL OF VETERINARY CLINICAL RESEARCH Year:2013 | Volume:4 | Issue:1 (13) Page(s): 1-10

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Title

COMPARISON OF THE EFFECTS OF OMPERAZOLE AND RABEPRAZOLE IN PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN RATS

Author(s)

Keywords

RABEPERAZOLEQ2

OMEPRAZOLEQ2

PEPTIC ULCERSQ2

RATQ2

Abstract

Peptic ulcer is a common disease in veterinary and human medicine. Protective factors in gastrointestinal tract contain: mucosal defense, prostaglandin G, local circulation, mucous, Antioxidants (vitamin E, vitamin C, melatonin, Superoxide dismutase). Ulcerogenic factors in gastrointestinal tract contain: HP, acid, pepcin, stress, Genetic, free radicals, NSAIDs, duodenogastric reflux, virus, zollinger- ellison syndrom. Indomethacin is a NSAID drug. OMEPRAZOLE, rabeprazole and pantoprazole are Proton Pump Inhibitor (PIP) drugs.This study have performed on 6 groups of RATs: saline, indomethacin, OMEPRAZOLE (10mg/kg)+indomethacin, omprazole (1mg/kg)+indomethacin, rabeprazole (10mg/kg) + indomethacin, rabeprazole (1mg/kg)+indomethacin. All RATs were killed 4 hours after the last injection of indomethacin and stomachs were prepared for calculation of j.score and histopathological study.In indomethacin group, injection of indomethacin was associated with significant increased in j.score compared with saline group. Injection of OMEPRAZOLE and rabeprazole, was associated with significant decrease in j.score compared with indomethacin group.Injection of rabeprazole, was associated with significant decrease in j.score compared with OMEPRAZOLE group. Histopathological results confirmed j.score results.

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References

THE EFFECTS OF SOME NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ON EXPERIMENTAL INDUCED GASTRIC ULCERS IN RATS

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APA: Copy

REZVANJOO, B., BAGHAIKIA, A., MOAYER, F., GHAFARI, M., & SHIRAZI BEHESHTIHA, S.H.. (2013). COMPARISON OF THE EFFECTS OF OMPERAZOLE AND RABEPRAZOLE IN PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN RATS. JOURNAL OF VETERINARY CLINICAL RESEARCH, 4(1 (13)), 1-10. SID. https://sid.ir/paper/233045/en

Vancouver: Copy

REZVANJOO B., BAGHAIKIA A., MOAYER F., GHAFARI M., SHIRAZI BEHESHTIHA S.H.. COMPARISON OF THE EFFECTS OF OMPERAZOLE AND RABEPRAZOLE IN PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN RATS. JOURNAL OF VETERINARY CLINICAL RESEARCH[Internet]. 2013;4(1 (13)):1-10. Available from: https://sid.ir/paper/233045/en

IEEE: Copy

B. REZVANJOO, A. BAGHAIKIA, F. MOAYER, M. GHAFARI, and S.H. SHIRAZI BEHESHTIHA, “COMPARISON OF THE EFFECTS OF OMPERAZOLE AND RABEPRAZOLE IN PREVENTION OF INDOMETHACIN INDUCED GASTRIC ULCERS IN RATS,” JOURNAL OF VETERINARY CLINICAL RESEARCH, vol. 4, no. 1 (13), pp. 1–10, 2013, [Online]. Available: https://sid.ir/paper/233045/en

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