The effect of Hydro-Alcoholic Extract of Plantago Major on Indomethacin-Induced Gastric Ulcer in Rats

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PASEBAN M.; Mousavi Fayzabadi v.; TAYYEBI MEIBODI N.; YOUSEFI M.; HOSSEINI A.; RAKHSHANDEH H.

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Journal: Internal Medicine Today Year:2019 | Volume:25 | Issue:1 Page(s): 16-21

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Title

The effect of Hydro-Alcoholic Extract of Plantago Major on Indomethacin-Induced Gastric Ulcer in Rats

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Keywords

Stomach ulcerQ3

IndomethacinQ3

Plantago majorQ1

Gastric acidQ1

Abstract

Aims: Plantago major is used in traditional medicine for the treatment of gastrointestinal disorders. The purpose of this study was to examine the effect of hydro – alcoholic extract of Plantago major on Indomethacin-induced gastric ulcer in rats. Materials & Methods: 72 male Wistar rats were used in this experimental study. In treatment groups, animals received Indomethacin (35 mg/kg) as single dose for induces Stomach ulcer, then rats were gavaged by ranitidine (50 mg/kg) and different doses of the extract (200 mg/kg, 400 mg/kg and 800 mg/kg) for 3 days. In preventive groups, animals were treated by ranitidine and different doses of extract for 3 days, and then Indomethacin was gavaged on 4th day for Stomach ulcer induction. Gastric mucosal damage and acid secretion were evaluated 6 hours later. Statistical analysis was performed using one-way ANOVA. Findings: Acid secretion significantly decreased in therapeutic group that received 200 mg/kg dose of the extract and in preventive groups that received different doses of the extract (p<0. 05). Also macroscopic results showed all doses of extract in preventive groups and 200 mg/kg and 800 mg/kg doses of extract in therapeutic groups significantly decreased ulcer index (p<0. 05, p<0. 01). Conclusion: Hydro – alcoholic extract of Plantago major can protect the gastric mucosa against Indomethacin-induced gastric ulcer, via decreasing of Gastric acid secretion.

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APA: Copy

PASEBAN, M., Mousavi Fayzabadi, v., TAYYEBI MEIBODI, N., YOUSEFI, M., HOSSEINI, A., & RAKHSHANDEH, H.. (2019). The effect of Hydro-Alcoholic Extract of Plantago Major on Indomethacin-Induced Gastric Ulcer in Rats. OFOGH-E-DANESH, 25(1 ), 16-21. SID. https://sid.ir/paper/68559/en

Vancouver: Copy

PASEBAN M., Mousavi Fayzabadi v., TAYYEBI MEIBODI N., YOUSEFI M., HOSSEINI A., RAKHSHANDEH H.. The effect of Hydro-Alcoholic Extract of Plantago Major on Indomethacin-Induced Gastric Ulcer in Rats. OFOGH-E-DANESH[Internet]. 2019;25(1 ):16-21. Available from: https://sid.ir/paper/68559/en

IEEE: Copy

M. PASEBAN, v. Mousavi Fayzabadi, N. TAYYEBI MEIBODI, M. YOUSEFI, A. HOSSEINI, and H. RAKHSHANDEH, “The effect of Hydro-Alcoholic Extract of Plantago Major on Indomethacin-Induced Gastric Ulcer in Rats,” OFOGH-E-DANESH, vol. 25, no. 1 , pp. 16–21, 2019, [Online]. Available: https://sid.ir/paper/68559/en

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