PREPARATION AND CHARACTERIZATION OF ESCHERICHIA COLI LIPOSOMES AS A NEW DRUG DELIVERY SYSTEM TO COLON CANCER

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KARGAR MOHAMMAD; HANDALI SOMAYEH; MOGHIMIPOUR ESKANDAR; RAMEZANI ZAHRA

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Journal: BIOLOGICAL JOURNAL OF MICROORGANISM Year:2016 | Volume:5 | Issue:17 Page(s): 87-96

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Title

PREPARATION AND CHARACTERIZATION OF ESCHERICHIA COLI LIPOSOMES AS A NEW DRUG DELIVERY SYSTEM TO COLON CANCER

Author(s)

KARGAR MOHAMMAD | HANDALI SOMAYEH | MOGHIMIPOUR ESKANDAR | RAMEZANI ZAHRA | Issue Writer Certificate

Keywords

LIPOSOMEQ1

E.COLI.Q1

FILM LAYERQ1

ENCAPSULATIONQ1

Abstract

Introduction: LIPOSOMEs are spherical vesicles composed of concentric phospholipid bilayers that can entrap hydrophilic, hydrophobic drugs. LIPOSOMEs can be prepared from natural phospholipids, synthetic lipids or bacterial lipids. The aim of this study was to formulate LIPOSOME from bacterial lipids and evaluate physicochemical properties.Materials and methods: This study was performed experimentally on E.COLI. The lipids were extracted from E.COLI. using chloroform and methanol. Film method was used for preparing nano-systems and methylene blue was used as a drug model. Then their particle sizes were determined using particle sizer. The release methylene blue was carried out using dialysis membrane. Also, trailing them in cancer cells was evaluated by using carboxyfluorescein.Results: The average particle size of E.COLI. liposomal was 338 nm. ENCAPSULATION efficiency was 53.33±2.88% and the value of release after 24 h was 97.54%±0.00. LIPOSOMEs could deliver the carboxyfluorescein to cancer cells.Discussion and conclusion: The results of this study demonstrated that bacterial LIPOSOME has probably a suitable nano-particle such as particle size and desirable loading and it is possible to use them as drug delivery system.

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APA: Copy

KARGAR, MOHAMMAD, HANDALI, SOMAYEH, MOGHIMIPOUR, ESKANDAR, & RAMEZANI, ZAHRA. (2016). PREPARATION AND CHARACTERIZATION OF ESCHERICHIA COLI LIPOSOMES AS A NEW DRUG DELIVERY SYSTEM TO COLON CANCER. BIOLOGICAL JOURNAL OF MICROORGANISM, 5(17), 87-96. SID. https://sid.ir/paper/237303/en

Vancouver: Copy

KARGAR MOHAMMAD, HANDALI SOMAYEH, MOGHIMIPOUR ESKANDAR, RAMEZANI ZAHRA. PREPARATION AND CHARACTERIZATION OF ESCHERICHIA COLI LIPOSOMES AS A NEW DRUG DELIVERY SYSTEM TO COLON CANCER. BIOLOGICAL JOURNAL OF MICROORGANISM[Internet]. 2016;5(17):87-96. Available from: https://sid.ir/paper/237303/en

IEEE: Copy

MOHAMMAD KARGAR, SOMAYEH HANDALI, ESKANDAR MOGHIMIPOUR, and ZAHRA RAMEZANI, “PREPARATION AND CHARACTERIZATION OF ESCHERICHIA COLI LIPOSOMES AS A NEW DRUG DELIVERY SYSTEM TO COLON CANCER,” BIOLOGICAL JOURNAL OF MICROORGANISM, vol. 5, no. 17, pp. 87–96, 2016, [Online]. Available: https://sid.ir/paper/237303/en

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