THE EFFECT OF ALKALOID EXTRACT OF SOPHORA ALOPECUROIDES ON MIC VALUE AND INTRACELLULAR ACCUMULATION OF RCIPROFLOXACIN IN A CIPROFLOXACIN RESISTANT MUTANT OF ESCHERICHIA COLI

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MOHAMADI P.; POURAHMAD R.; SHAREGHI B.; FARHADIAN S.

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Journal: Journal of Molecular and Cellular Researches Year:2017 | Volume:30 | Issue:3 Page(s): 323-335

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Title

THE EFFECT OF ALKALOID EXTRACT OF SOPHORA ALOPECUROIDES ON MIC VALUE AND INTRACELLULAR ACCUMULATION OF RCIPROFLOXACIN IN A CIPROFLOXACIN RESISTANT MUTANT OF ESCHERICHIA COLI

Author(s)

MOHAMADI P. | POURAHMAD R. | SHAREGHI B. | FARHADIAN S. | Issue Writer Certificate

Keywords

DRUG RESISTANCEQ1

CIPROFLOXACINQ1

SOPHORA ALOPECUROIDESQ1

SPECTROFLUOROMETRYQ1

Abstract

Infections, which are caused by multiple DRUG RESISTANCE bacteria is an increasing problem. This is due to emergence and distribution of microbial DRUG RESISTANCE, and none development of new antibiotics. The use of phytochemical products and plant extract as a resistance reducing agent is an increasingly active subject of research. This study was aimed to study the effect of total alkaloides extract of SOPHORA ALOPECUROIDES on Minimum Inhibitory Concentration value and intracellular accumulation of CIPROFLOXACIN in an Escherichia coli CIPROFLOXACIN resistant mutant. For this purpose serial dilution method for determining Minimum Inhibitory Concentration value and spectrofluorometric assay assays for measuring intracellular accumulation of CIPROFLOXACIN antibiotic were used. Results showed that plant extract decreased CIPROFLOXACIN Minimum Inhibitory Concentration. This extract also increased intracellular accumulation of antibiotic in the Escherichia coli CIPROFLOXACIN resistant mutant. In conclusion, extract containing alkaloids of SOPHORA ALOPECUROIDES can increase sensitivity to CIPROFLOXACIN in resistant mutants through its effect on membrane efflux pump, AcrAB-TolC.

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APA: Copy

MOHAMADI, P., POURAHMAD, R., SHAREGHI, B., & FARHADIAN, S.. (2017). THE EFFECT OF ALKALOID EXTRACT OF SOPHORA ALOPECUROIDES ON MIC VALUE AND INTRACELLULAR ACCUMULATION OF RCIPROFLOXACIN IN A CIPROFLOXACIN RESISTANT MUTANT OF ESCHERICHIA COLI. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 30(3 ), 323-335. SID. https://sid.ir/paper/248545/en

Vancouver: Copy

MOHAMADI P., POURAHMAD R., SHAREGHI B., FARHADIAN S.. THE EFFECT OF ALKALOID EXTRACT OF SOPHORA ALOPECUROIDES ON MIC VALUE AND INTRACELLULAR ACCUMULATION OF RCIPROFLOXACIN IN A CIPROFLOXACIN RESISTANT MUTANT OF ESCHERICHIA COLI. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2017;30(3 ):323-335. Available from: https://sid.ir/paper/248545/en

IEEE: Copy

P. MOHAMADI, R. POURAHMAD, B. SHAREGHI, and S. FARHADIAN, “THE EFFECT OF ALKALOID EXTRACT OF SOPHORA ALOPECUROIDES ON MIC VALUE AND INTRACELLULAR ACCUMULATION OF RCIPROFLOXACIN IN A CIPROFLOXACIN RESISTANT MUTANT OF ESCHERICHIA COLI,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 30, no. 3 , pp. 323–335, 2017, [Online]. Available: https://sid.ir/paper/248545/en

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