مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

ULTRA-SENSITIVE, RAPID GOLD NANO ROD-QUANTUM DOT (RQ) PLEXCITONIC SELF-ASSEMBLED APTAMER-BASED NANOBIOSENSOR FOR THE DETECTION OF HUMAN CARDIAC TROPONIN I

Pages

  131-140

Abstract

 ACUTE MYOCARDIAL INFARCTION (AMI) is one of the leading causes of death throughout the world. Usual methods for detecting AMI are expensive, time-consuming and using blood samples as biological samples. Therefore, creating an ultra-fast, sensitive and non-invasive diagnostic test is necessary. Herein, a novel ultra-sensitive, fluorescent, plasmon-exciton coupling hybrid of a Gold Nano Rod-Quantum Dot (RQ) -based APTAMER NANOBIOSENSOR is presented for the detection of HUMAN CARDIAC TROPONIN I (cTnI), the golden biomarker of AMI, and a preclinical test is performed with saliva. The binding of the cTnI protein to APTAMER leads to a fluorescence enhancement of the plexcitonic hybrid system. The limit of detection of this NANOBIOSENSOR is 0.5 fM. It seems this novel NANOBIOSENSOR of the RQ plexcitonic hybrid system can open up new opportunities for the design and fabrication of NANOBIOSENSOR progress in Nano biotechnology.

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    APA: Copy

    REZAEI, Z., & RANJBAR, B.. (2015). ULTRA-SENSITIVE, RAPID GOLD NANO ROD-QUANTUM DOT (RQ) PLEXCITONIC SELF-ASSEMBLED APTAMER-BASED NANOBIOSENSOR FOR THE DETECTION OF HUMAN CARDIAC TROPONIN I. NANOSCALE, 2(3), 131-140. SID. https://sid.ir/paper/256981/en

    Vancouver: Copy

    REZAEI Z., RANJBAR B.. ULTRA-SENSITIVE, RAPID GOLD NANO ROD-QUANTUM DOT (RQ) PLEXCITONIC SELF-ASSEMBLED APTAMER-BASED NANOBIOSENSOR FOR THE DETECTION OF HUMAN CARDIAC TROPONIN I. NANOSCALE[Internet]. 2015;2(3):131-140. Available from: https://sid.ir/paper/256981/en

    IEEE: Copy

    Z. REZAEI, and B. RANJBAR, “ULTRA-SENSITIVE, RAPID GOLD NANO ROD-QUANTUM DOT (RQ) PLEXCITONIC SELF-ASSEMBLED APTAMER-BASED NANOBIOSENSOR FOR THE DETECTION OF HUMAN CARDIAC TROPONIN I,” NANOSCALE, vol. 2, no. 3, pp. 131–140, 2015, [Online]. Available: https://sid.ir/paper/256981/en

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