NIOSOME- AND LIPOSOME-LOADED CALCIUM ALGINATE MICROHYDROGELS FOR ENCAPSULATION AND SUSTAINABLE RELEASE OF HYDROPHILIC LOW MOLECULAR WEIGHT COMPOUNDS

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MEHREGAN NIKOO ALIREZA; KADKHODAEE RASSOUL; GHORANI BEHROUZ

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Paper Information

Journal: JOURNAL OF INNOVATIVE FOOD TECHNOLOGIES (JIFT) Year:2017 | Volume:4 | Issue:15 Page(s): 11-24

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Title

NIOSOME- AND LIPOSOME-LOADED CALCIUM ALGINATE MICROHYDROGELS FOR ENCAPSULATION AND SUSTAINABLE RELEASE OF HYDROPHILIC LOW MOLECULAR WEIGHT COMPOUNDS

Author(s)

MEHREGAN NIKOO ALIREZA | KADKHODAEE RASSOUL | GHORANI BEHROUZ | Issue Writer Certificate

Keywords

FILLED HYDROGELQ1

LIPOSOMEQ1

NIOSOMEQ1

CAFFEINEQ1

ELECTROSPRAYQ1

ENCAPSULATIONQ1

Abstract

Calcium alginate micro hydrogels loaded with NIOSOMEs and LIPOSOMEs were used to encapsulate CAFFEINE as a model low molecular weight hydrophilic bioactive compound. To load NIOSOMEs and LIPOSOMEs into alginate hydrogel network and to reduce the size of gel particles the feed solution was electro sprayed into calcium chloride solution. Successive freeze-thaw cycles were employed with a view to slow the release rate of CAFFEINE from NIOSOMEs and LIPOSOMEs. The results showed that NIOSOMEs was more efficient in CAFFEINE ENCAPSULATION than LIPOSOMEs. The release profiles confirmed the positive effect of freeze-thaw cycles on sustainable release of CAFFEINE and that the NIOSOME-loaded hydrogels had slower rate of CAFFEINE release. Also, LIPOSOMEs made of highly pure lecithin revealed more ENCAPSULATION efficiency as well as better release profile compared to those of commercial lecithin. Korsmeyer-Peppasmodel was found to appropriately describe the release of CAFFEINE from particles based on Fickian diffusion. The findings of this study clearly demonstrated that NIOSOME- and LIPOSOME- loaded micro hydrogels could potentially be used to encapsulate food and pharmaceutical compounds for slow release applications. Moreover, electro spraying technique owing to its capability of producing uniform fine particles could be used as an alternative method for hydrogel preparation from natural polymers.

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APA: Copy

MEHREGAN NIKOO, ALIREZA, KADKHODAEE, RASSOUL, & GHORANI, BEHROUZ. (2017). NIOSOME- AND LIPOSOME-LOADED CALCIUM ALGINATE MICROHYDROGELS FOR ENCAPSULATION AND SUSTAINABLE RELEASE OF HYDROPHILIC LOW MOLECULAR WEIGHT COMPOUNDS. JOURNAL OF INNOVATIVE FOOD TECHNOLOGIES (JIFT), 4(15 ), 11-24. SID. https://sid.ir/paper/258718/en

Vancouver: Copy

MEHREGAN NIKOO ALIREZA, KADKHODAEE RASSOUL, GHORANI BEHROUZ. NIOSOME- AND LIPOSOME-LOADED CALCIUM ALGINATE MICROHYDROGELS FOR ENCAPSULATION AND SUSTAINABLE RELEASE OF HYDROPHILIC LOW MOLECULAR WEIGHT COMPOUNDS. JOURNAL OF INNOVATIVE FOOD TECHNOLOGIES (JIFT)[Internet]. 2017;4(15 ):11-24. Available from: https://sid.ir/paper/258718/en

IEEE: Copy

ALIREZA MEHREGAN NIKOO, RASSOUL KADKHODAEE, and BEHROUZ GHORANI, “NIOSOME- AND LIPOSOME-LOADED CALCIUM ALGINATE MICROHYDROGELS FOR ENCAPSULATION AND SUSTAINABLE RELEASE OF HYDROPHILIC LOW MOLECULAR WEIGHT COMPOUNDS,” JOURNAL OF INNOVATIVE FOOD TECHNOLOGIES (JIFT), vol. 4, no. 15 , pp. 11–24, 2017, [Online]. Available: https://sid.ir/paper/258718/en

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