SIMULTANEOUS DETERMINATION OF CAPTOPRIL AND HYDROCHLOROTHIAZIDE BY FTIR SPECTROMETRY USING MULTIVARIATE CALIBRATION TECHNIQUE IN PHARMACEUTICAL FORMULATIONS

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KARGOSHA K.; AHMADI SEYED HAMID; REZAEI LALEH; MANSOURIAN MAHBOUBEH

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Journal: Nashrieh Shimi va Mohandesi Shimi Iran Year:2009 | Volume:27 | Issue:4 Page(s): 19-27

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Title

SIMULTANEOUS DETERMINATION OF CAPTOPRIL AND HYDROCHLOROTHIAZIDE BY FTIR SPECTROMETRY USING MULTIVARIATE CALIBRATION TECHNIQUE IN PHARMACEUTICAL FORMULATIONS

Author(s)

KARGOSHA K. | AHMADI SEYED HAMID | REZAEI LALEH | MANSOURIAN MAHBOUBEH | Issue Writer Certificate

Keywords

FT-IR SPECTROMETRYQ3

PARTIAL LEAST SQUAREQ3

HYDROCHLOROTHIAZIDEQ3

CAPTOPRILQ3

PHARMACEUTICAL FORMULATIONQ3

Abstract

In the present research, a rapid and ease procedure for simultaneous determination of CAPTOPRIL and HYDROCHLOROTHIAZIDE of overlapping spectra in tablets using Fourier-transform infrared spectrometry (FT-IR) and multivariate calibration methods has been applied. For all chemometric calibrations, a concentration set of mixture of CAPTOPRIL (Cpt) and HYDROCHLOROTHIAZIDE (Hctz) according to Full-Factorial desing in dimethylsufoxide (DMSO) solvent was prepared. Then Number of factors, number of scans and the resolution was optimized and FT-IR transmission spectra were recorded in the spectral region of 4000-800 cm-1. The investigated calibrations were tested for the synthetic mixtures consisting of two drugs using the Omnic Quant IR software. The results of the methods were compared with UV-VIS reference method and a good agreement was found. Among three of the chemometric methods which were used, PLS (partial least-squares) first order derivative spectra method have the best results. The statistical parameters such as RMSEC (root mean square error of calibration), RMSECV (root mean square error of cross validation) and SEP (standard error of prediction) for Cpt and Hctz were obtained 0.134, 0.154, 0.043 and 0.192, 0.224, 0.044 (mg per 10 ml) respectively. Relative standard deviation (RSD) for jive independent analyses and recovery were 1.2%, 98.67% and 1.8%, 98.42% for Cpt and Hctz respectively.Regression coefficient (R2) of calibration curves was excellent. The main advantage of investigated method is the fast and simultaneous analysis for the several components in mixture without any chemical pretreatment as separation in HPLC and derivation in derivative spectrometry.

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APA: Copy

KARGOSHA, K., AHMADI, SEYED HAMID, REZAEI, LALEH, & MANSOURIAN, MAHBOUBEH. (2009). SIMULTANEOUS DETERMINATION OF CAPTOPRIL AND HYDROCHLOROTHIAZIDE BY FTIR SPECTROMETRY USING MULTIVARIATE CALIBRATION TECHNIQUE IN PHARMACEUTICAL FORMULATIONS. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), 27(4), 19-27. SID. https://sid.ir/paper/26302/en

Vancouver: Copy

KARGOSHA K., AHMADI SEYED HAMID, REZAEI LALEH, MANSOURIAN MAHBOUBEH. SIMULTANEOUS DETERMINATION OF CAPTOPRIL AND HYDROCHLOROTHIAZIDE BY FTIR SPECTROMETRY USING MULTIVARIATE CALIBRATION TECHNIQUE IN PHARMACEUTICAL FORMULATIONS. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN)[Internet]. 2009;27(4):19-27. Available from: https://sid.ir/paper/26302/en

IEEE: Copy

K. KARGOSHA, SEYED HAMID AHMADI, LALEH REZAEI, and MAHBOUBEH MANSOURIAN, “SIMULTANEOUS DETERMINATION OF CAPTOPRIL AND HYDROCHLOROTHIAZIDE BY FTIR SPECTROMETRY USING MULTIVARIATE CALIBRATION TECHNIQUE IN PHARMACEUTICAL FORMULATIONS,” NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), vol. 27, no. 4, pp. 19–27, 2009, [Online]. Available: https://sid.ir/paper/26302/en

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