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Information Journal Paper

Title

Interactive effects of peripheral and central administration of LPS with inhibition of CRF receptors on food intake in neonatal chicks

Pages

  19-25

Keywords

Corticotrophin-releasing factor (CRF) receptors 

Abstract

 Anorexia is a part of the acute phase response (APR). Lipopolysaccharide (LPS) is frequently used to mimic APR and induces anorexia. Th e mechanism underlying anorexia associated with APR in chicks is not well understood. In the present study, the possible involvement of corticotrophin-releasing factor (CRF) on anorexic eff ects of LPS in Neonatal chicks was investigated. For this aim, diff erent doses of LPS were administrated via both intracerebroventricular (ICV) and intraperitoneal (IP) routes in order to assess its eff ects on chick’ s food intake. Subsequently, the eff ect of ICV injection of astressin, a CRF receptor antagonist, on anorexia induced by ICV and IP administration of LPS was investigated. Food intake was signifi cantly decreased following either central or systemic administration of LPS. ICV co-injection of astressin and LPS signifi cantly diminished anorexic eff ects of central LPS. However, anorexia induced by peripheral LPS was not attenuated by central injection of astressin. Th ese data indicated that the brain CRF receptors are involved in central LPS-induced anorexia in chicks.

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  • Cite

    APA: Copy

    Jonaidi, Hossein, ABBASNEJAD, MEHDI, Soltaninejad, Mohadese, Sharifi mehr, Abdolhamid, Kooshki, Razieh, Yosoufi, Manochehr, & Aghapour, mobin. (2019). Interactive effects of peripheral and central administration of LPS with inhibition of CRF receptors on food intake in neonatal chicks. IRANIAN JOURNAL OF VETERINARY SCIENCE AND TECHNOLOGY, 11(1 ), 19-25. SID. https://sid.ir/paper/269146/en

    Vancouver: Copy

    Jonaidi Hossein, ABBASNEJAD MEHDI, Soltaninejad Mohadese, Sharifi mehr Abdolhamid, Kooshki Razieh, Yosoufi Manochehr, Aghapour mobin. Interactive effects of peripheral and central administration of LPS with inhibition of CRF receptors on food intake in neonatal chicks. IRANIAN JOURNAL OF VETERINARY SCIENCE AND TECHNOLOGY[Internet]. 2019;11(1 ):19-25. Available from: https://sid.ir/paper/269146/en

    IEEE: Copy

    Hossein Jonaidi, MEHDI ABBASNEJAD, Mohadese Soltaninejad, Abdolhamid Sharifi mehr, Razieh Kooshki, Manochehr Yosoufi, and mobin Aghapour, “Interactive effects of peripheral and central administration of LPS with inhibition of CRF receptors on food intake in neonatal chicks,” IRANIAN JOURNAL OF VETERINARY SCIENCE AND TECHNOLOGY, vol. 11, no. 1 , pp. 19–25, 2019, [Online]. Available: https://sid.ir/paper/269146/en

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