SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND DNA BINDING STUDIES OF DIIMINE PLATINUM(II) AND PALLADIUM(II) COMPLEXES OF SHORT HYDROCARBON CHAIN ETHYLDITHIOCARBAMATE LIGAND

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ESLAMI MOGHADAM M.; MANSOURI TORSHIZI H.; DIVSALAR A.; SABOURI A.A.

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Journal Paper

Paper Information

Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2009 | Volume:6 | Issue:3 Page(s): 552-569

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Information Journal Paper

Title

SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND DNA BINDING STUDIES OF DIIMINE PLATINUM(II) AND PALLADIUM(II) COMPLEXES OF SHORT HYDROCARBON CHAIN ETHYLDITHIOCARBAMATE LIGAND

Author(s)

ESLAMI MOGHADAM M. | MANSOURI TORSHIZI H. | DIVSALAR A. | SABOURI A.A. | Issue Writer Certificate

Keywords

CYTOTOXICITY

PLATINUM(II) AND PALLADIUM(II) COMPLEXES

ETHYLDITHIOCARBAMATE

DNA BINDING

Abstract

Two novel Platinum (II) and Palladium (II) complexes of 2, 2'-bipyridine (bpy) with ETHYLDITHIOCARBAMATE (Et-dtc) were synthesized. These complexes were characterized by spectroscopic methods such as ultraviolet-visible, infrared and 1H NMR as well as conductivity measurements and chemical analysis. In these complexes, the dithiocarbamate ligand coordinates with Pt(II) or Pd(II) center as bidentate with two sulfur atoms. These water soluble complexes were tested for their in vitro anti-tumor activity against chronic myelogenous leukemia cell line, K562. They show Cc50 values lower than those of cisplatin. The mode of binding of the complexes to calf thymus DNA, were investigated by circular dichroism, ultraviolet difference and fluorescence spectroscopy. These complexes can denature DNA at very low concentrations (~100 mM). Both complexes exhibit cooperative binding and presumably intercalate into DNA. Remarkably, most of the experimental results indicate that the tendency of the Pd (II) complex to interact with DNA and its anti-tumor activity against K562 is more than that of its Pt (II) analog.

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APA: Copy

ESLAMI MOGHADAM, M., MANSOURI TORSHIZI, H., DIVSALAR, A., & SABOURI, A.A.. (2009). SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND DNA BINDING STUDIES OF DIIMINE PLATINUM(II) AND PALLADIUM(II) COMPLEXES OF SHORT HYDROCARBON CHAIN ETHYLDITHIOCARBAMATE LIGAND. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 6(3), 552-569. SID. https://sid.ir/paper/282325/en

Vancouver: Copy

ESLAMI MOGHADAM M., MANSOURI TORSHIZI H., DIVSALAR A., SABOURI A.A.. SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND DNA BINDING STUDIES OF DIIMINE PLATINUM(II) AND PALLADIUM(II) COMPLEXES OF SHORT HYDROCARBON CHAIN ETHYLDITHIOCARBAMATE LIGAND. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2009;6(3):552-569. Available from: https://sid.ir/paper/282325/en

IEEE: Copy

M. ESLAMI MOGHADAM, H. MANSOURI TORSHIZI, A. DIVSALAR, and A.A. SABOURI, “SYNTHESIS, CHARACTERIZATION, CYTOTOXIC AND DNA BINDING STUDIES OF DIIMINE PLATINUM(II) AND PALLADIUM(II) COMPLEXES OF SHORT HYDROCARBON CHAIN ETHYLDITHIOCARBAMATE LIGAND,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 6, no. 3, pp. 552–569, 2009, [Online]. Available: https://sid.ir/paper/282325/en

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