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Information Journal Paper

Title

ENANTIOSELECTIVE EXTRACTION OF MANDELIC ACID ENANTIOMERS BY AQUEOUS TWO-PHASE SYSTEMS OF POLYETHYLENE GLYCOL AND AMMONIUM SULFATE CONTAINING β-CYCLODEXTRIN AS CHIRAL SELECTOR

Pages

  889-896

Abstract

 A new CHIRAL SEPARATION technology, aqueous two-phase extraction, was proposed for the separation of racemic mandelic acid.The distribution behavior of MANDELIC ACID ENANTIOMERS was investigated in aqueous two-phase systems composed of polyethylene glycol and ammonium sulfate containing b-cyclodextrin as chiral selector. The influences of the pH, the mass fraction of polyethylene glycol and ammonium sulfate, the polymerization degree of polyethylene glycol, the initial concentration of b-cyclodextrin, MANDELIC ACID ENANTIOMERS and extractive temperature on the distribution behavior were studied respectively. The results show that b-cyclodextrin is inclined to recognize L-enantiomer; under the optimized conditions, the separation factor reaches 2.46 and the enantiomeric excess is 42.13% in the top phase and 40.43% in the bottom phase, respectively. Aqueous two phase chiral-extraction with strong CHIRAL SEPARATION ability, plays great role in preparative separation of racemic compounds and is important for the development of AQUEOUS TWO PHASE EXTRACTION technique.

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  • Cite

    APA: Copy

    TAN, L., LONG, Y., JIAO, F., & CHEN, X.. (2011). ENANTIOSELECTIVE EXTRACTION OF MANDELIC ACID ENANTIOMERS BY AQUEOUS TWO-PHASE SYSTEMS OF POLYETHYLENE GLYCOL AND AMMONIUM SULFATE CONTAINING β-CYCLODEXTRIN AS CHIRAL SELECTOR. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 8(4), 889-896. SID. https://sid.ir/paper/282630/en

    Vancouver: Copy

    TAN L., LONG Y., JIAO F., CHEN X.. ENANTIOSELECTIVE EXTRACTION OF MANDELIC ACID ENANTIOMERS BY AQUEOUS TWO-PHASE SYSTEMS OF POLYETHYLENE GLYCOL AND AMMONIUM SULFATE CONTAINING β-CYCLODEXTRIN AS CHIRAL SELECTOR. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2011;8(4):889-896. Available from: https://sid.ir/paper/282630/en

    IEEE: Copy

    L. TAN, Y. LONG, F. JIAO, and X. CHEN, “ENANTIOSELECTIVE EXTRACTION OF MANDELIC ACID ENANTIOMERS BY AQUEOUS TWO-PHASE SYSTEMS OF POLYETHYLENE GLYCOL AND AMMONIUM SULFATE CONTAINING β-CYCLODEXTRIN AS CHIRAL SELECTOR,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 8, no. 4, pp. 889–896, 2011, [Online]. Available: https://sid.ir/paper/282630/en

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