SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE

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SALEHI PEYMAN; AYYARI MAHDI; BARARJANIAN MORTEZA; NEJAD EBRAHIMI SAMAD; ALIAHMADI ATOUSA

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Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2014 | Volume:11 | Issue:3 Page(s): 607-613

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Title

SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE

Author(s)

Keywords

3-DIHYDROQUINAZOLIN-4(1H)-ONES

DEHYDROABIETYLAMINE

DIASTEREOMERS

MULTI-COMPONENT REACTION

Abstract

A series of novel 2,3-dihydroquinazolin-4(1H)-ones was synthesized by a three-component reaction between DEHYDROABIETYLAMINE (DHA) diterpene, isatoic anhydride and different aromatic aldehydes in the presence of a catalytic amount of p-toluenesulfonic acid (13 mol%). Diastereomeric products were separated by preparative thin-layer chromatography and their structures were characterized by1H and 13C NMR, HMQC, IR and HR-ESI-MS. Antioxidant activities of the synthesized compounds were assessed by two different methods including DPPH and β-carotene-linoleic acid bleaching assays. Antibacterial activities of the compounds were also evaluated against two Gram-positive and one Gram-negative bacterial strains and in the case of Bacillus cereus a considerable inhibitory effect (MIC 4–16 mg/ml) was observed.

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APA: Copy

SALEHI, PEYMAN, AYYARI, MAHDI, BARARJANIAN, MORTEZA, NEJAD EBRAHIMI, SAMAD, & ALIAHMADI, ATOUSA. (2014). SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 11(3), 607-613. SID. https://sid.ir/paper/282753/en

Vancouver: Copy

SALEHI PEYMAN, AYYARI MAHDI, BARARJANIAN MORTEZA, NEJAD EBRAHIMI SAMAD, ALIAHMADI ATOUSA. SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2014;11(3):607-613. Available from: https://sid.ir/paper/282753/en

IEEE: Copy

PEYMAN SALEHI, MAHDI AYYARI, MORTEZA BARARJANIAN, SAMAD NEJAD EBRAHIMI, and ATOUSA ALIAHMADI, “SYNTHESIS, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF NOVEL 2, 3-DIHYDROQUINAZOLIN-4 (1H) -ONE DERIVATIVES OF DEHYDROABIETYLAMINE DITERPENE,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 11, no. 3, pp. 607–613, 2014, [Online]. Available: https://sid.ir/paper/282753/en

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