SYNTHESIS AND ANTITUMOR EVALUATION OF SOME NEW BISCARBOXAMIDOCOUMARIN AND CHROMENE DERIVATIVES

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REFAT HALA M.; FADDA A.A.; KAMAL SHIMAA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2015 | Volume:12 | Issue:5 Page(s): 845-854

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Title

SYNTHESIS AND ANTITUMOR EVALUATION OF SOME NEW BISCARBOXAMIDOCOUMARIN AND CHROMENE DERIVATIVES

Author(s)

REFAT HALA M. | FADDA A.A. | KAMAL SHIMAA

Keywords

ENAMINONITRILE

CHROMENE

CARBOXAMIDE

ANTITUMOR ACTIVITY

Abstract

The reaction of N, N’-(1, 4-phenylene) bis (2-cyano-3-(dimethylamino) acrylamide) (2) with resorcinol, a-naphthol, b-naphthol, dimedone and indandione in acetic acid afforded bischromene derivatives 4, 6, 8, 12 and 14, respectively. Similarly, treatment of 2 with barbituric acid, thiobarbituric acid and 3-methyl-1-phenyl-1H-pyrazol-5 (4H)-one to give pyrano [2, 3-b] pyrimidine 16, 18, and pyrano [2, 3-c] pyrazole 20 derivatives. Moreover, 2 react with thiocyanoacetamide to afford 2-pyridone derivative24. The newly synthesized compounds were evaluated as antitumor activities. The results showed that four compounds, namely 4, 10, 18 and 24, displayed promising in vitro ANTITUMOR ACTIVITY in the four cell lines assay.

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APA: Copy

REFAT, HALA M., FADDA, A.A., & KAMAL, SHIMAA. (2015). SYNTHESIS AND ANTITUMOR EVALUATION OF SOME NEW BISCARBOXAMIDOCOUMARIN AND CHROMENE DERIVATIVES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 12(5), 845-854. SID. https://sid.ir/paper/283166/en

Vancouver: Copy

REFAT HALA M., FADDA A.A., KAMAL SHIMAA. SYNTHESIS AND ANTITUMOR EVALUATION OF SOME NEW BISCARBOXAMIDOCOUMARIN AND CHROMENE DERIVATIVES. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2015;12(5):845-854. Available from: https://sid.ir/paper/283166/en

IEEE: Copy

HALA M. REFAT, A.A. FADDA, and SHIMAA KAMAL, “SYNTHESIS AND ANTITUMOR EVALUATION OF SOME NEW BISCARBOXAMIDOCOUMARIN AND CHROMENE DERIVATIVES,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 12, no. 5, pp. 845–854, 2015, [Online]. Available: https://sid.ir/paper/283166/en

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