NEW 3-HYDROXY-2-NAPHTHOIC HYDRAZIDE DERIVATIVES: THIOSEMICARBAZIDES AND 1,2,4-TRIAZOLE-3-THIONES, THEIR SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION

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POPIOLEK LUKASZ; PARUCH KINGA; PATREJKO PAWEL; BIERNASIUK ANNA; WUJEC MONIKA

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Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2016 | Volume:13 | Issue:10 Page(s): 0-0

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Title

NEW 3-HYDROXY-2-NAPHTHOIC HYDRAZIDE DERIVATIVES: THIOSEMICARBAZIDES AND 1,2,4-TRIAZOLE-3-THIONES, THEIR SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION

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Keywords

3-HYDROXY-2-NAPHTHOIC HYDRAZIDE1

4-TRIAZOLE DERIVATIVES THIOSEMICARBAZIDE

DERIVATIVES ANTIMICROBIAL ACTIVITY MICMBC

Abstract

In this paper, we describe twelve 3-hydroxy-2-naphthoic hydrazide derivatives (six thiosemicarbazides and six 1, 2, 4-triazole-3-thiones) which we have synthesized. Thiosemicarbazide derivatives were prepared by condensation reaction of 3-hydroxy-2-naphthoic hydrazide with appropriate isothiocyanates. The 1, 2, 4-triazole-3-thiones were synthesized by the cyclization reaction of corresponding thiosemicarbazide derivatives in alkaline media. All obtained compounds have been analyzed by 1H NMR and 13C NMR spectra and evaluated for in vitro antimicrobial activity against a panel of reference strains of microorganisms, including Gram-positive bacteria, Gram-negative bacteria and fungi belonging to yeasts Candida spp. Our antimicrobial screening results indicated that some of the newly obtained compounds showed high antibacterial activity, especially against Gram-positive bacteria. Among them, the activity of compounds 1, 2 and 4 was moderate to strong against staphylococci. In addition to this, compounds 1 and 2 showed two times higher activity than cefuroxime and four times higher activity than ampicillin against Bacillus cereus ATCC 10876.

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APA: Copy

POPIOLEK, LUKASZ, PARUCH, KINGA, PATREJKO, PAWEL, WUJEC, MONIKA, & BIERNASIUK, ANNA. (2016). NEW 3-HYDROXY-2-NAPHTHOIC HYDRAZIDE DERIVATIVES: THIOSEMICARBAZIDES AND 1,2,4-TRIAZOLE-3-THIONES, THEIR SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 13(10), 0-0. SID. https://sid.ir/paper/283238/en

Vancouver: Copy

POPIOLEK LUKASZ, PARUCH KINGA, PATREJKO PAWEL, WUJEC MONIKA, BIERNASIUK ANNA. NEW 3-HYDROXY-2-NAPHTHOIC HYDRAZIDE DERIVATIVES: THIOSEMICARBAZIDES AND 1,2,4-TRIAZOLE-3-THIONES, THEIR SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2016;13(10):0-0. Available from: https://sid.ir/paper/283238/en

IEEE: Copy

LUKASZ POPIOLEK, KINGA PARUCH, PAWEL PATREJKO, MONIKA WUJEC, and ANNA BIERNASIUK, “NEW 3-HYDROXY-2-NAPHTHOIC HYDRAZIDE DERIVATIVES: THIOSEMICARBAZIDES AND 1,2,4-TRIAZOLE-3-THIONES, THEIR SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 13, no. 10, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/283238/en

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