NEW DOUBLE-WALLED PH-SENSITIVE HYDROGEL SYSTEMS CONTAINING NANOPARTICLE DRUG FOR COLON-SPECIFIC DRUG DELIVERY

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MAHKAM M.; RANAEI SIADAT S.O.

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Journal: International Journal of Nanoscience and Nanotechnology Year:2006 | Volume:2 | Issue:1 Page(s): 19-26

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Title

NEW DOUBLE-WALLED PH-SENSITIVE HYDROGEL SYSTEMS CONTAINING NANOPARTICLE DRUG FOR COLON-SPECIFIC DRUG DELIVERY

Author(s)

MAHKAM M. | RANAEI SIADAT S.O.

Keywords

CORE-SHELL

PH-SENSITIVE

HYDROGEL

ORAL DRUG DELIVERY

COLON

Abstract

Double-walled (DW) polymer with a Core of mixture of nano or microparticles of carboxymethyl cellulose sodium (CMC) salt and a model drug olsalazine [3, 3=azobis (6-hydroxy benzoic acid)] (OSZ) as an azo derivatives of 5-aminosalicylic acid (5-ASA) and an external coat of cross-linked copolymers of (acrylamido methyl) cellulose acetate butyrate (AMCAB) and methacrylic acid (MAA) with various amounts of f, 6-hexandiol diacrylate (HDD) are considerd as cross-linking agents (CA). The core with nano composite was prepared byfreeze drying method and then used as nuclei for subsequent shell copolymerization. The structure of core was characterized with scanning electron microscopy. The double-walled HYDROGELs were characterized by differential scanning calorimetry and FT-fR. Studies of drug release were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The drug-release profiles indicated that the amount of drug released depended on the shell layer composition. The releasing was modulated by the amount of cross-linking in shell layer. Based on the great difference in hydrolysis rates at pH 1 and 7.4, these PH-SENSITIVE HYDROGELs appear to be good
Candidates for COLON-specific drug delivery.

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APA: Copy

MAHKAM, M., & RANAEI SIADAT, S.O.. (2006). NEW DOUBLE-WALLED PH-SENSITIVE HYDROGEL SYSTEMS CONTAINING NANOPARTICLE DRUG FOR COLON-SPECIFIC DRUG DELIVERY. INTERNATIONAL JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (IJNN), 2(1), 19-26. SID. https://sid.ir/paper/300083/en

Vancouver: Copy

MAHKAM M., RANAEI SIADAT S.O.. NEW DOUBLE-WALLED PH-SENSITIVE HYDROGEL SYSTEMS CONTAINING NANOPARTICLE DRUG FOR COLON-SPECIFIC DRUG DELIVERY. INTERNATIONAL JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (IJNN)[Internet]. 2006;2(1):19-26. Available from: https://sid.ir/paper/300083/en

IEEE: Copy

M. MAHKAM, and S.O. RANAEI SIADAT, “NEW DOUBLE-WALLED PH-SENSITIVE HYDROGEL SYSTEMS CONTAINING NANOPARTICLE DRUG FOR COLON-SPECIFIC DRUG DELIVERY,” INTERNATIONAL JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (IJNN), vol. 2, no. 1, pp. 19–26, 2006, [Online]. Available: https://sid.ir/paper/300083/en

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