EVALUATION OF SYNTHESIZED PLATINUM NANOPARTICLES ON THE MCF-7 AND HEPG-2 CANCER CELL LINES

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MOHAMMADI HADI; ABEDI ANITA; AKBARZADEH AZIM; MOKHTARI MOHAMMAD JAVAD; EBRAHIMI SHAHMABADI HASAN; MEHRABI MOHAMAD REZA; JAVADIAN SAIFUDDIN; CHIANI MOHSEN

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Journal: INTERNATIONAL NANO LETTERS (INL) Year:2013 | Volume:3 | Issue:3 Page(s): 1-5

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Title

EVALUATION OF SYNTHESIZED PLATINUM NANOPARTICLES ON THE MCF-7 AND HEPG-2 CANCER CELL LINES

Author(s)

Keywords

PLATINUM NANOPARTICLES

POTASSIUM HEXACHLOROPLATINATE

CHEMICAL REDUCTION

MTT ASSAY

MCF-7

HEPG-2

Abstract

PLATINUM NANOPARTICLES (PNPs) were synthesized by CHEMICAL REDUCTION of POTASSIUM HEXACHLOROPLATINATE (IV) with trisodium citrate under vigorous stirring and addition of sodium dodecyl sulfate as stabilizer reagent. Reducing agent was chosen depending on the oxidation reactions and potential values of the chemical materials used in the experiment. The aim of this study is to investigate the effects of PNPs on the different cancer cell lines and cytotoxicity study of this nanomaterial. The morphology of PNPs was investigated by scanning electron microscope (XL30, Philips Electronics, Amsterdam, The Netherlands) with the ability to perform elemental analysis by EDX.Malvern Zetasizer 3000 HSA (Malvern Instruments, Worcestershire, UK) was used to determine the distribution of particle size and zeta potential of PNPs. The cytotoxicity property of the nanoparticles was evaluated by MTT ASSAY on MCF-7 and HEPG-2 cell lines, and the cytotoxic concentration 50% values were determined for 24 h.

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EVALUATION OF NATIVE AND EXOTIC BRAZILIAN PLANTS FOR ANTICANCER ACTIVITY

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APA: Copy

MOHAMMADI, HADI, ABEDI, ANITA, AKBARZADEH, AZIM, MOKHTARI, MOHAMMAD JAVAD, EBRAHIMI SHAHMABADI, HASAN, MEHRABI, MOHAMAD REZA, JAVADIAN, SAIFUDDIN, & CHIANI, MOHSEN. (2013). EVALUATION OF SYNTHESIZED PLATINUM NANOPARTICLES ON THE MCF-7 AND HEPG-2 CANCER CELL LINES. INTERNATIONAL NANO LETTERS (INL), 3(3), 1-5. SID. https://sid.ir/paper/321368/en

Vancouver: Copy

MOHAMMADI HADI, ABEDI ANITA, AKBARZADEH AZIM, MOKHTARI MOHAMMAD JAVAD, EBRAHIMI SHAHMABADI HASAN, MEHRABI MOHAMAD REZA, JAVADIAN SAIFUDDIN, CHIANI MOHSEN. EVALUATION OF SYNTHESIZED PLATINUM NANOPARTICLES ON THE MCF-7 AND HEPG-2 CANCER CELL LINES. INTERNATIONAL NANO LETTERS (INL)[Internet]. 2013;3(3):1-5. Available from: https://sid.ir/paper/321368/en

IEEE: Copy

HADI MOHAMMADI, ANITA ABEDI, AZIM AKBARZADEH, MOHAMMAD JAVAD MOKHTARI, HASAN EBRAHIMI SHAHMABADI, MOHAMAD REZA MEHRABI, SAIFUDDIN JAVADIAN, and MOHSEN CHIANI, “EVALUATION OF SYNTHESIZED PLATINUM NANOPARTICLES ON THE MCF-7 AND HEPG-2 CANCER CELL LINES,” INTERNATIONAL NANO LETTERS (INL), vol. 3, no. 3, pp. 1–5, 2013, [Online]. Available: https://sid.ir/paper/321368/en

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