IN VITRO RELEASE STUDIES OF ENOXAPARIN IN NANOPARTICLE FORM AND ENTERICALLY COATED TABLETS CONTAINING SURFACTANTS

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GHORBAN DADRASS ORKIDEH; GOHARZADEH MORVARID; AVADI MOHAMMAD REZA; GHASSEMI ZAHRA; MIRMOHAMMAD SADEGHI ASAL

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Journal: Journal of Applied Chemical Research Year:2014 | Volume:8 | Issue:3 Page(s): 7-16

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Title

IN VITRO RELEASE STUDIES OF ENOXAPARIN IN NANOPARTICLE FORM AND ENTERICALLY COATED TABLETS CONTAINING SURFACTANTS

Author(s)

Keywords

ENOXAPARIN

NANOPARTICLES

ENHANCER AGENTS

TRIMETHYL CHITOSAN

RELEASE STUDIES

Abstract

In the past decade, many strategies have been developed to enhance oral drug delivery. Different techniques were investigated, amongst those the use of permeation enhancers such surfactants and biodegradable polymers were studied more extensively. Chitosan and its derivatives have been studied as permeation enhancer. The aim of the current study was to develop a nanoparticulate system based on ionic interaction between TRIMETHYL CHITOSAN (TMC) and ENOXAPARIN and comparing the release profile of ENOXAPARIN from enterically coated tablets containing surfactants such as Tween 80 and Sodium Lauryl Sulfate (SLS) as permeation enhancer. The prepared NANOPARTICLES were characterized for size, zeta potential, loading capacity and in vitro release. The tablets were enterically coated, characterized physically and were assayed for their content. The release of ENOXAPARIN was studied in PBS pH 6.8 corresponding to the pH of small intestine. The result suggested that the NANOPARTICLES were positively charged with a diameter of about 120 nm and loading capacity of around 95%. The tablets contained 60 mg of ENOXAPARIN and 10 mg of surfactant as permeation enhancer. The in vitro release from tablets showed almost 100% ENOXAPARIN release in 2 hours; whereas in NANOPARTICLES there was a 67.5% release in 24 hours. In order to better evaluate the enhancing effect of the polymer and surfactants in nanoparticle form and oral dosage tablet, further ex vivo and in vivo studies are required.

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APA: Copy

GHORBAN DADRASS, ORKIDEH, GOHARZADEH, MORVARID, AVADI, MOHAMMAD REZA, GHASSEMI, ZAHRA, & MIRMOHAMMAD SADEGHI, ASAL. (2014). IN VITRO RELEASE STUDIES OF ENOXAPARIN IN NANOPARTICLE FORM AND ENTERICALLY COATED TABLETS CONTAINING SURFACTANTS. JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR), 8(3), 7-16. SID. https://sid.ir/paper/322927/en

Vancouver: Copy

GHORBAN DADRASS ORKIDEH, GOHARZADEH MORVARID, AVADI MOHAMMAD REZA, GHASSEMI ZAHRA, MIRMOHAMMAD SADEGHI ASAL. IN VITRO RELEASE STUDIES OF ENOXAPARIN IN NANOPARTICLE FORM AND ENTERICALLY COATED TABLETS CONTAINING SURFACTANTS. JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR)[Internet]. 2014;8(3):7-16. Available from: https://sid.ir/paper/322927/en

IEEE: Copy

ORKIDEH GHORBAN DADRASS, MORVARID GOHARZADEH, MOHAMMAD REZA AVADI, ZAHRA GHASSEMI, and ASAL MIRMOHAMMAD SADEGHI, “IN VITRO RELEASE STUDIES OF ENOXAPARIN IN NANOPARTICLE FORM AND ENTERICALLY COATED TABLETS CONTAINING SURFACTANTS,” JOURNAL OF APPLIED CHEMICAL RESEARCH (JACR), vol. 8, no. 3, pp. 7–16, 2014, [Online]. Available: https://sid.ir/paper/322927/en

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