IMMUNOGENIC EVALUATION OF CHIMERIC RECOMBINANT PROTEIN AGAINST ETEC, EHEC AND SHIGELLA

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KHALOUIE FARZANE; MOUSAVI SEYED LATIF; NAZARIAN SHAHRAM; AMANI JAFAR; POURFARZAM POUNE

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Journal Paper

Paper Information

Journal: MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS Year:2017 | Volume:6 | Issue:3 Page(s): 101-112

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Title

IMMUNOGENIC EVALUATION OF CHIMERIC RECOMBINANT PROTEIN AGAINST ETEC, EHEC AND SHIGELLA

Author(s)

Keywords

CHIMERIC VACCINE

IPAC

CFAB

INTIMIN

Abstract

Diarrheal diseases still remain health problem worldwide and out of many bacteria responsible for, Shigella and pathogenic Escherichia cause the most diarrheas in the world. Shigella cause bacterial dysenteries and shigellosis through invasion where the most effective proteins for pathogenesis is IPAC. Critical virulence protein for ETEC infection is CFA/I with two subunits called CFAB and cfae.. Attachment of EHEC is the main step of infection and the protein INTIMIN plays the key role in this function. Protection against the vast majority of responsible pathogens of diarrheas requires development of the combination vaccine against Shigella, ETEC and EHEC. In the present study, a multisubunitprotein (CII) containing immunologically significant parts of CFAB, IPAC and INTIMIN was designed. The chimeric gene (CII) was codon optimized and analyzed with different bioinformatic servers, then synthesized and expressed in E. coli. Mice, Guinea pig and, Caco-2 Cell line were used as challenge models for EHEC, shigella and ETEC respectively. The chimeric protein induced significant immune response and therefore could be a suitable vaccine candidate against these three pathogens.

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APA: Copy

KHALOUIE, FARZANE, MOUSAVI, SEYED LATIF, NAZARIAN, SHAHRAM, AMANI, JAFAR, & POURFARZAM, POUNE. (2017). IMMUNOGENIC EVALUATION OF CHIMERIC RECOMBINANT PROTEIN AGAINST ETEC, EHEC AND SHIGELLA. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, 6(3), 101-112. SID. https://sid.ir/paper/336237/en

Vancouver: Copy

KHALOUIE FARZANE, MOUSAVI SEYED LATIF, NAZARIAN SHAHRAM, AMANI JAFAR, POURFARZAM POUNE. IMMUNOGENIC EVALUATION OF CHIMERIC RECOMBINANT PROTEIN AGAINST ETEC, EHEC AND SHIGELLA. MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS[Internet]. 2017;6(3):101-112. Available from: https://sid.ir/paper/336237/en

IEEE: Copy

FARZANE KHALOUIE, SEYED LATIF MOUSAVI, SHAHRAM NAZARIAN, JAFAR AMANI, and POUNE POURFARZAM, “IMMUNOGENIC EVALUATION OF CHIMERIC RECOMBINANT PROTEIN AGAINST ETEC, EHEC AND SHIGELLA,” MOLECULAR BIOLOGY RESEARCH COMMUNICATIONS, vol. 6, no. 3, pp. 101–112, 2017, [Online]. Available: https://sid.ir/paper/336237/en

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