SYNTHESIS AND EVALUATION OF MEPEG-PCL DIBLOCK COPOLYMERS: SURFACE PROPERTIES AND CONTROLLED RELEASE BEHAVIOR

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MOHANTY ANJAN KUMAR; JANA UTPAL; MANNA PRABAL KUMAR; MOHANTA GURU PRASAD

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Journal Paper

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Journal: PROGRESS IN BIOMATERIALS Year:2015 | Volume:4 | Issue:2 Page(s): 0-0

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Title

SYNTHESIS AND EVALUATION OF MEPEG-PCL DIBLOCK COPOLYMERS: SURFACE PROPERTIES AND CONTROLLED RELEASE BEHAVIOR

Author(s)

MOHANTY ANJAN KUMAR | JANA UTPAL | MANNA PRABAL KUMAR | MOHANTA GURU PRASAD | Issue Writer Certificate

Keywords

BIODEGRADABLE POLYMERS

DRUG CARRIER

MICELLE

CMC

EPR EFFECT

Abstract

The amphiphilic block copolymers are composed of various combinations of hydrophilic and hydrophobic block unimers. The variation in unimer ratio alters the surface aswell asmicelle-forming properties of the block copolymers. These nanoscopic MICELLEs have the ability to encapsulate hydrophobic compounds and act as potential DRUG CARRIER. MePEG-PCL copolymers with various block lengths were synthesized by ring-opening polymerization and characterized by 1HNMR, GPC, WXRD and DSC. The number average molecular weight of the block copolymer was found to vary from 7511 to 21, 270 as determined by GPC and 1HNMR studies. The surface topology of the polymer films was determined by AFM analysis, which shows a smoother surfacewith increased MePEG contents in the block copolymers. The protein-binding assay indicates a better biocompatibility of the block copolymers in comparison to MePEG or PCL alone. The CMC of the block copolymer provides the information about MICELLE formations for encapsulation of hydrophobic materials and affects the in vitro release.

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APA: Copy

MOHANTY, ANJAN KUMAR, JANA, UTPAL, MANNA, PRABAL KUMAR, & MOHANTA, GURU PRASAD. (2015). SYNTHESIS AND EVALUATION OF MEPEG-PCL DIBLOCK COPOLYMERS: SURFACE PROPERTIES AND CONTROLLED RELEASE BEHAVIOR. PROGRESS IN BIOMATERIALS, 4(2), 0-0. SID. https://sid.ir/paper/336482/en

Vancouver: Copy

MOHANTY ANJAN KUMAR, JANA UTPAL, MANNA PRABAL KUMAR, MOHANTA GURU PRASAD. SYNTHESIS AND EVALUATION OF MEPEG-PCL DIBLOCK COPOLYMERS: SURFACE PROPERTIES AND CONTROLLED RELEASE BEHAVIOR. PROGRESS IN BIOMATERIALS[Internet]. 2015;4(2):0-0. Available from: https://sid.ir/paper/336482/en

IEEE: Copy

ANJAN KUMAR MOHANTY, UTPAL JANA, PRABAL KUMAR MANNA, and GURU PRASAD MOHANTA, “SYNTHESIS AND EVALUATION OF MEPEG-PCL DIBLOCK COPOLYMERS: SURFACE PROPERTIES AND CONTROLLED RELEASE BEHAVIOR,” PROGRESS IN BIOMATERIALS, vol. 4, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/336482/en

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