PEG-PENETRATED CHITOSAN–ALGINATE CO-POLYSACCHARIDE-BASED PARTIALLY AND FULLY CROSS-LINKED HYDROGELS AS ECM MIMIC FOR TISSUE ENGINEERING APPLICATIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RADHAKRISHNAN ANITHA; JOSE GEENA MARIYA; KURUP MURALEEDHARA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PROGRESS IN BIOMATERIALS Year:2015 | Volume:4 | Issue:2 Page(s): 0-0

Download Full-Text

View:

462

Download:

108

Cites:

Information Journal Paper

Title

PEG-PENETRATED CHITOSAN–ALGINATE CO-POLYSACCHARIDE-BASED PARTIALLY AND FULLY CROSS-LINKED HYDROGELS AS ECM MIMIC FOR TISSUE ENGINEERING APPLICATIONS

Author(s)

RADHAKRISHNAN ANITHA | JOSE GEENA MARIYA | KURUP MURALEEDHARA | Issue Writer Certificate

Keywords

TISSUE ENGINEERING

CROSS-LINKED HYDROGELS

ALGINATE

CHITOSAN

ECM MIMIC

Abstract

The emerging strategy of TISSUE ENGINEERING for the management of end-stage organ failure and associated complications mainly relies on ECM MIMICking scaffolds for neo-tissue genesis. In the current study, novel polyethylene glycol interpenetrated cross-linked hydrogel scaffold based on a co-polysaccharide (PIAC) synthesized from two marine heteropolysaccharides, ALGINATE and CHITOSAN, was designed. Partially cross-linked (PIAC-P) and fully CROSS-LINKED HYDROGELS (PIAC-F) were prepared. The physiochemical evaluations of both the hydrogels revealed the presence of ALGINATE fraction and extensive -OH groups on the surface, sufficient water content and water holding capacity. The porosity and bulk density were also appreciable. The scaffolds were hemocompatible and were able to adsorb appreciable plasma proteins on to the surface. MTT assay on hydrogel extracts and direct contact assay showed the nontoxic effects of fibroblast cells upon contact with the hydrogel. Live/dead assay using ethidium bromide/ acridine orange cocktail on fibroblast cells grown on the hydrogels after 5 days of initial seeding displayed green nucleus revealing the non-apoptotic cells. PIAC-P hydrogels were superior to certain aspects due to the availability of free functional groups than PIAC-F where most of these groups were utilized for cross-linking. The biological evaluations confirmed the healthy being and 3D growth of fibroblasts on the porous networks of both the hydrogels. The present hydrogel can form an ECM MIMIC and can form a potent candidate for various TISSUE ENGINEERING applications.

Cites

No record.

References

No record.

Cite

APA: Copy

RADHAKRISHNAN, ANITHA, JOSE, GEENA MARIYA, & KURUP, MURALEEDHARA. (2015). PEG-PENETRATED CHITOSAN–ALGINATE CO-POLYSACCHARIDE-BASED PARTIALLY AND FULLY CROSS-LINKED HYDROGELS AS ECM MIMIC FOR TISSUE ENGINEERING APPLICATIONS. PROGRESS IN BIOMATERIALS, 4(2), 0-0. SID. https://sid.ir/paper/336483/en

Vancouver: Copy

RADHAKRISHNAN ANITHA, JOSE GEENA MARIYA, KURUP MURALEEDHARA. PEG-PENETRATED CHITOSAN–ALGINATE CO-POLYSACCHARIDE-BASED PARTIALLY AND FULLY CROSS-LINKED HYDROGELS AS ECM MIMIC FOR TISSUE ENGINEERING APPLICATIONS. PROGRESS IN BIOMATERIALS[Internet]. 2015;4(2):0-0. Available from: https://sid.ir/paper/336483/en

IEEE: Copy

ANITHA RADHAKRISHNAN, GEENA MARIYA JOSE, and MURALEEDHARA KURUP, “PEG-PENETRATED CHITOSAN–ALGINATE CO-POLYSACCHARIDE-BASED PARTIALLY AND FULLY CROSS-LINKED HYDROGELS AS ECM MIMIC FOR TISSUE ENGINEERING APPLICATIONS,” PROGRESS IN BIOMATERIALS, vol. 4, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/336483/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops