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Title

Biofabrication and characterization of flavonoid‑ loaded Ag, Au, Au– Ag bimetallic nanoparticles using seed extract of the plant Madhuca longifolia for the enhancement in wound healing bio‑ efficacy

Pages

  51-63

Abstract

 The present communication warrants the presence of significant wound healing bio-efficacy of aq. alc. extract of the seed (49. 78%) of the plant Madhuca longifolia. A family of seven flavonoid fractions have been ascertained in the seed aq. alc. extract of the target plant using LCMS-8030 analysis. In vivo wound healing parameters (wound area, wound closure, epithelization period, skin breaking strength and hydroxyproline content) have been examined in Swiss albino mice models. Statistically significant (p < 0. 001) enhancement in the wound healing bio-efficacy has been effectively induced using flavonoid-loaded gold: ( Mlf@AuNps), silver: ( Mlf@AgNps), and Au– Ag bimetallic: ( Mlf@Au– AgNps) nanoparticles. Among the biofabricated nano-biomaterials, Mlf@ AgNps exhibited an exceptional enhancement in the wound healing bio-efficacy (80. 33%) attaining almost to the level of reference drug Placentrex (84. 02%). All the fabricated nano-biomaterials were thoroughly characterized using UV– Vis, XRD, FE-SEM, TEM, EDX, and DLS. The promising enhancement in the wound healing potential of the nano-biomaterial ( Mlf@AgNps) has been explained based on the cumulative effects of biological and nanotech parameters. The bio-fabricated ( Mlf@AgNps) nano-biomaterials using the plant M. longifolia have lustrous prospects for the development of complimentary herbal nanomedicine for scaling-up the wound healing bio-efficacy.

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    APA: Copy

    Sharma, Mukti, Yadav, Saurabh, Ganesh, Narayanan, Srivastava, Man Mohan, & SRIVASTAVA, SHALINI. (2019). Biofabrication and characterization of flavonoid‑ loaded Ag, Au, Au– Ag bimetallic nanoparticles using seed extract of the plant Madhuca longifolia for the enhancement in wound healing bio‑ efficacy. PROGRESS IN BIOMATERIALS, 8(1), 51-63. SID. https://sid.ir/paper/336544/en

    Vancouver: Copy

    Sharma Mukti, Yadav Saurabh, Ganesh Narayanan, Srivastava Man Mohan, SRIVASTAVA SHALINI. Biofabrication and characterization of flavonoid‑ loaded Ag, Au, Au– Ag bimetallic nanoparticles using seed extract of the plant Madhuca longifolia for the enhancement in wound healing bio‑ efficacy. PROGRESS IN BIOMATERIALS[Internet]. 2019;8(1):51-63. Available from: https://sid.ir/paper/336544/en

    IEEE: Copy

    Mukti Sharma, Saurabh Yadav, Narayanan Ganesh, Man Mohan Srivastava, and SHALINI SRIVASTAVA, “Biofabrication and characterization of flavonoid‑ loaded Ag, Au, Au– Ag bimetallic nanoparticles using seed extract of the plant Madhuca longifolia for the enhancement in wound healing bio‑ efficacy,” PROGRESS IN BIOMATERIALS, vol. 8, no. 1, pp. 51–63, 2019, [Online]. Available: https://sid.ir/paper/336544/en

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