COMPARATIVE EVALUATION OF EOSINOPHILS IN NORMAL MUCOSA, DYSPLASTIC MUCOSA AND ORAL SQUAMOUS CELL CARCINOMA WITH HEMATOXYLIN-EOSIN, CONGO RED, AND EMR1 IMMUNOHISTOCHEMICAL STAINING TECHNIQUES

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KARGAHI NEDA; RAZAVI SAYED MOHAMMAD; DEYHIMI PARVIZ; HOMAYOUNI TORABINEJAD SOLMAZ

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Journal: ELECTRONIC PHYSICIAN Year:2015 | Volume:7 | Issue:2 Page(s): 1019-1026

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Title

COMPARATIVE EVALUATION OF EOSINOPHILS IN NORMAL MUCOSA, DYSPLASTIC MUCOSA AND ORAL SQUAMOUS CELL CARCINOMA WITH HEMATOXYLIN-EOSIN, CONGO RED, AND EMR1 IMMUNOHISTOCHEMICAL STAINING TECHNIQUES

Author(s)

KARGAHI NEDA | RAZAVI SAYED MOHAMMAD | DEYHIMI PARVIZ | HOMAYOUNI TORABINEJAD SOLMAZ | Issue Writer Certificate

Keywords

CONGO RED

DYSPLASTIC

EMR1

EOSINOPHIL

NORMAL MUCOSA

SQUAMOUS CELL CARCINOMA

Abstract

Background: Oral SQUAMOUS CELL CARCINOMA is the most common malignant lesion of the oral cavity, and it involves various molecular mechanisms. The development of oral SQUAMOUS CELL CARCINOMA is influenced by the host immune cells, such as EOSINOPHILs. The present study was conducted to compare the presence of EOSINOPHILs in NORMAL MUCOSA, DYSPLASTIC mucosa, and oral SQUAMOUS CELL CARCINOMA by -hematoxylin- eosin staining, CONGO RED staining, and epidermal growth factor-like (EGF-like) module containing a mucin-like hormone receptor1 (EMR1) immunohistochemical marker.Methods: In this cross-sectional study, 60 paraffinized samples were selected, consisting of 20 NORMAL MUCOSAe, 20 DYSPLASTIC mucosae, and 20 SQUAMOUS CELL CARCINOMA samples. After confirmation of the diagnosis, the mean number of EOSINOPHILs was evaluated by hematoxylin-eosin, CONGO RED, and immunohystochemical staining techniques. The data were analyzed by SPSS-10 software using the Kruskal-Wallis and Friedman tests.Results: The results showed that the number of EOSINOPHILs in DYSPLASTIC mucosa was significantly higher than the number in NORMAL MUCOSA, and the number of EOSINOPHILs in SQUAMOUS CELL CARCINOMA was significantly higher than the number in DYSPLASTIC mucosa in all staining techniques (p<0.001). Moreover, the comparison of staining techniques showed a significantly higher number of EOSINOPHILs in EMR1immunohistochemicalmarker than were observed when CONGO RED and hematoxylin - eosin (H&E) staining techniques were used (p<0.001).Conclusion: It can be argued that EOSINOPHIL contributes to the identification of lesions that have a higher potential of malignant transformation. Moreover, EOSINOPHIL can be suggested as an indicator in the differentiation of oral lesions in cases with borderline diagnosis and in targeted molecular therapy

Cites

TISSUE EOSINOPHILS AS A HISTOPATHOLOGICAL MARKER IN ORAL PREMALIGNANT AND MALIGNANT LESIONS: A HISTOCHEMICAL STUDY

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APA: Copy

KARGAHI, NEDA, RAZAVI, SAYED MOHAMMAD, DEYHIMI, PARVIZ, & HOMAYOUNI TORABINEJAD, SOLMAZ. (2015). COMPARATIVE EVALUATION OF EOSINOPHILS IN NORMAL MUCOSA, DYSPLASTIC MUCOSA AND ORAL SQUAMOUS CELL CARCINOMA WITH HEMATOXYLIN-EOSIN, CONGO RED, AND EMR1 IMMUNOHISTOCHEMICAL STAINING TECHNIQUES. ELECTRONIC PHYSICIAN, 7(2), 1019-1026. SID. https://sid.ir/paper/345330/en

Vancouver: Copy

KARGAHI NEDA, RAZAVI SAYED MOHAMMAD, DEYHIMI PARVIZ, HOMAYOUNI TORABINEJAD SOLMAZ. COMPARATIVE EVALUATION OF EOSINOPHILS IN NORMAL MUCOSA, DYSPLASTIC MUCOSA AND ORAL SQUAMOUS CELL CARCINOMA WITH HEMATOXYLIN-EOSIN, CONGO RED, AND EMR1 IMMUNOHISTOCHEMICAL STAINING TECHNIQUES. ELECTRONIC PHYSICIAN[Internet]. 2015;7(2):1019-1026. Available from: https://sid.ir/paper/345330/en

IEEE: Copy

NEDA KARGAHI, SAYED MOHAMMAD RAZAVI, PARVIZ DEYHIMI, and SOLMAZ HOMAYOUNI TORABINEJAD, “COMPARATIVE EVALUATION OF EOSINOPHILS IN NORMAL MUCOSA, DYSPLASTIC MUCOSA AND ORAL SQUAMOUS CELL CARCINOMA WITH HEMATOXYLIN-EOSIN, CONGO RED, AND EMR1 IMMUNOHISTOCHEMICAL STAINING TECHNIQUES,” ELECTRONIC PHYSICIAN, vol. 7, no. 2, pp. 1019–1026, 2015, [Online]. Available: https://sid.ir/paper/345330/en

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