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Information Journal Paper

Title

OVERALL SURVIVAL IN ADULT PATIENTS WITH LOW-GRADE, SUPRATENTORIAL GLIOMA: TEN YEARS’ FOLLOW UP AT A SINGLE INSTITUTION

Pages

  1114-1120

Abstract

 Background: LOW-GRADE GLIOMAs (LGGs) are the second most prevalent type of primary brain tumors in adults. The prognosis for LGGs can differ according to the clinical-pathological PROGNOSTIC FACTORS determined during diagnosis and treatment. The purpose of this study was to identify 10-year, DISEASE-FREE SURVIVAL (DFS), 10-year OVERALL SURVIVAL (OS), and related clinical-pathological PROGNOSTIC FACTORS of adult patients with supratentorial, LOW-GRADE GLIOMAs who were treated with or without surgery and radiation therapy.Methods: The study included 110 patients who were confirmed to have low-grade, supratentorial gliomas and who had received surgery and adjuvant radiation therapy or salvage RADIOTHERAPY as part of their treatment. These patients were followed by the radiation-oncology ward at Shohada-e-Tajrish Hospital in Tehran, Iran, between 2002 and 2012. The log-rank test (univariate) and the Cox proportional hazards model (multivariate) were used to examine the 10-year DFS and OS and to assess the strengths of various histo-clinical factors relative to 10-year DFS and OS.Results: The study included 110 patients for whom 10-year DFS and OS were found to be 23 and 28%, respectively. Favorable PROGNOSTIC FACTORS in the univariate analysis using the Kaplan-Meier 10-year OS analysis were the following: age below 40, karnofsky performance status (KPS) more than 70, the presence of oligodendroglioma, tumor size of < 5 cm, and gross-total resection (p=0.02, p=0.01, p=0.03, p=0.01, p=0.02, respectively). Good PROGNOSTIC FACTORS in multivariate analysis using the Cox regression model were as follows: age below 40, the presence of oligodendroglioma, tumor size< 5 cm, and gross total resection in10-year OS (p=0.01, p=0.03, p=0.00, p=0.02, respectively).Conclusions: Gross-total resection, tumor size < 5 cm, age below 40, and the presence of oligodendroglioma had better 10-year DFS and OS rates. We recommend that all patients with LGG tumors be referred to neurooncology centers that have sufficient experience to achieve the best results of treatment.

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    APA: Copy

    YOUSEFI KASHI, AMIR SHAHRAM, RAKHSHA, AFSHIN, & HOUSHYARI, MOHAMMAD. (2015). OVERALL SURVIVAL IN ADULT PATIENTS WITH LOW-GRADE, SUPRATENTORIAL GLIOMA: TEN YEARS’ FOLLOW UP AT A SINGLE INSTITUTION. ELECTRONIC PHYSICIAN, 7(3), 1114-1120. SID. https://sid.ir/paper/345341/en

    Vancouver: Copy

    YOUSEFI KASHI AMIR SHAHRAM, RAKHSHA AFSHIN, HOUSHYARI MOHAMMAD. OVERALL SURVIVAL IN ADULT PATIENTS WITH LOW-GRADE, SUPRATENTORIAL GLIOMA: TEN YEARS’ FOLLOW UP AT A SINGLE INSTITUTION. ELECTRONIC PHYSICIAN[Internet]. 2015;7(3):1114-1120. Available from: https://sid.ir/paper/345341/en

    IEEE: Copy

    AMIR SHAHRAM YOUSEFI KASHI, AFSHIN RAKHSHA, and MOHAMMAD HOUSHYARI, “OVERALL SURVIVAL IN ADULT PATIENTS WITH LOW-GRADE, SUPRATENTORIAL GLIOMA: TEN YEARS’ FOLLOW UP AT A SINGLE INSTITUTION,” ELECTRONIC PHYSICIAN, vol. 7, no. 3, pp. 1114–1120, 2015, [Online]. Available: https://sid.ir/paper/345341/en

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